Content Word Production during Discourse in Aphasia: Deficits in Word Quantity, Not Lexical-Semantic Complexity.
Content Word Production during Discourse in Aphasia: Deficits in Word Quantity, Not Lexical-Semantic Complexity.
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DOI：
10.1162/jocn_a_01772
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发表时间：
2021-11-05
影响因子：
3.2
通讯作者：
Lambon Ralph MA
中科院分区：
文献类型：
--
作者：
Alyahya RSW;Halai AD;Conroy P;Lambon Ralph MA
虽然有限和减少的连接言语产出是失语症的显著特征之一，但与许多关于单词产出的研究相比，很少有研究考察失语症患者在话语过程中产生的实词的特点。在这项研究中，我们使用分布分析方法研究了46名慢性卒中后失语患者和20名神经典型成年人在语篇中产生实词的特点，使用了三种语篇类型(描述性、叙事性和程序性)的不同刺激。首先，我们考察了语篇数据中实词的产生量、词汇-语义多样性和心理语言特征(频率和形象性)。随后，我们创建了一个对细微变化敏感的词汇-语义图景，并使我们能够评估跨群体语篇产生的变化模式。与神经典型成年人相比，所有失语症患者(无论是流利还是非流利)都表现出产出数量和多样性的显著减少，但词汇-语义产生的复杂性直接反映了神经典型表现。具体来说，失语症患者产生的名词/动词比率相同，他们的语篇样本涵盖了全部词频和想象能力，尽管词量有所减少。这些发现提供了新的证据表明，与其他障碍(如语义性痴呆)不同，中风后失语症的语篇产生相对保持了词汇-语义的复杂性，但表现出显著的内容词产生的数量减少。使用单变量和多变量方法的体素损害-症状图显示，在连接的言语过程中，左额叶区域，特别是盖部、岛叶皮质以及中央和额叶顶叶皮质支持单词提取，而与词类或其词汇-语义复杂性无关。
Although limited and reduced connected speech production is one, if not the most, prominent feature of aphasia, few studies have examined the properties of content words produced during discourse in aphasia, in comparison to the many investigations of single-word production. In this study, we used a distributional analysis approach to investigate the properties of content words production during discourse by 46 participants spanning a wide range of chronic post-stroke aphasia and 20 neuro-typical adults, using different stimuli that elicited three discourse genres (descriptive, narrative and procedural). Initially, we inspected the discourse data with respect to the quantity of production, lexical-semantic diversity, and psycholinguistic features (frequency and imageability) of content words. Subsequently, we created a ‘lexical-semantic landscape’, which is sensitive to subtle changes and allowed us to evaluate the pattern of changes in discourse production across groups. Relative to neuro-typical adults, all persons with aphasia (both fluent and non-fluent) showed significant reduction in the quantity and diversity of production, but the lexical-semantic complexity of word production directly mirrored neuro-typical performance. Specifically, persons with aphasia produced the same rate of nouns/verbs and their discourse samples covered the full range of word frequency and imageability, albeit with reduced word quantity. These findings provide novel evidence that, unlike in other disorders (e.g., semantic dementia), discourse production in post-stroke aphasia has relatively preserved lexical-semantic complexity but demonstrates significantly compromised quantity of content word production. Voxel-wise lesion-symptom mapping using both univariate and multivariate approaches revealed left frontal regions particularly the pars opercularis, insular cortex, and central and frontal opercular cortices supporting word retrieval during connected speech, irrespective of word class or their lexical-semantic complexity.
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影响因子：
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