Vaginal and Penile Microbiome Associations With Herpes Simplex Virus Type 2 in Women and Their Male Sex Partners.
Vaginal and Penile Microbiome Associations With Herpes Simplex Virus Type 2 in Women and Their Male Sex Partners.
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DOI：
10.1093/infdis/jiaa529
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发表时间：
2022-09-04
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影响因子：
--
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中科院分区：
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我们确定了阴道和阴茎微生物组如何影响性伴侣关系中单纯疱疹病毒2型（HSV-2）的血清状态。通过高通量16 s核糖体RNA基因扩增子测序，对宫颈阴道灌洗液和阴茎尿道拭子样本中的微生物组进行了表征。血清标本中检测到HSV-2抗体。我们使用双变量概率单位分析对女性和男性中导致HSV-2状态的阴道和阴茎分类群和协变量进行建模。在231对夫妇中，78对夫妇（33.8%）在双方中都检测到HSV-2，52对夫妇（22.5%）仅在女性中检测到HSV-2，27对夫妇（11.7%）仅在男性中检测到HSV-2，74对夫妇（32.0%）均未检测到HSV-2。在女性（中位年龄22岁）中，10.9%患有人类免疫缺陷病毒（HIV），21.4%患有细菌性阴道病。在男子中（中位年龄为26岁），11.8%的人感染艾滋病毒，55.0%的人做过包皮环切术。在一项调整了社会人口统计学和细菌性阴道病的分析中，阴道加德纳菌和惰性乳杆菌的富集与两个伴侣中HSV-2的可能性增加相关。阴茎分类群（包括脲原体和气球菌）与女性HSV-2相关。我们证明，阴茎类群与HSV-2的女性伴侣，阴道类群与HSV-2的男性伴侣。我们的研究结果表明，夫妻层面联合考虑生殖器微生物组和性传播感染或相关结果可能会带来新的预防途径。阴茎分类群与女性伴侣中的单纯疱疹病毒2型（HSV-2）相关，而阴道分类群与男性伴侣中的HSV-2相关。夫妇一级对生殖器微生物组的考虑可以为预防性传播感染和相关结果开辟新的途径。
We determined how the vaginal and penile microbiomes contribute to herpes simplex virus type 2 (HSV-2) serostatus within sexual partnerships. Microbiomes were characterized in cervicovaginal lavage and penile meatal swab specimens through high-throughput 16s ribosomal RNA gene amplicon sequencing. HSV-2 antibody was detected in serum specimens. We modeled vaginal and penile taxa and covariates contributing to HSV-2 status in women and men using bivariate probit analysis. Among 231 couples, HSV-2 was detected in both partners in 78 couples (33.8%), in the woman only in 52 (22.5%),in the man only in 27 (11.7%), and in neither in 74 (32.0%). Among the women (median age, 22 years) 10.9% had human immunodeficiency virus (HIV), and 21.4% had Bacterial vaginosis. Among men (median age, 26 years), 11.8% had HIV, and 55.0% circumcised. In an analysis with adjustment for sociodemographics and Bacterial vaginosis, enrichment of vaginal Gardnerella vaginalis and Lactobacillus iners was associated with increased likelihood of HSV-2 in both partners. Penile taxa (including Ureaplasma and Aerococcus) were associated with HSV-2 in women. We demonstrate that penile taxa are associated with HSV-2 in female partners, and vaginal taxa are associated with HSV-2 in male partners. Our findings suggest that couples-level joint consideration of genital microbiome and sexually transmitted infection or related outcomes could lead to new avenues for prevention. Penile taxa are associated with herpes simplex virus type 2 (HSV-2) in female partners, and vaginal taxa with HSV-2 in male partners. Couples-level consideration of the genital microbiome could open new avenues for preventing sexually transmitted infection and related outcomes.
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影响因子：
6.4
作者：
Liu CM;Hungate BA;Tobian AA;Serwadda D;Ravel J;Lester R;Kigozi G;Aziz M;Galiwango RM;Nalugoda F;Contente-Cuomo TL;Wawer MJ;Keim P;Gray RH;Price LB
通讯作者：
Price LB
DOI：
10.1016/s1473-3099(17)30405-x
发表时间：
2017-12
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Looker KJ;Elmes JAR;Gottlieb SL;Schiffer JT;Vickerman P;Turner KME;Boily MC
通讯作者：
Boily MC
影响因子：
3.7
作者：
Price LB;Liu CM;Johnson KE;Aziz M;Lau MK;Bowers J;Ravel J;Keim PS;Serwadda D;Wawer MJ;Gray RH
通讯作者：
Gray RH
DOI：
10.15698/mic2016.09.528
发表时间：
2016-06-27
期刊：
Microbial cell (Graz, Austria)
影响因子：
--
作者：
Jaishankar D;Shukla D
通讯作者：
Shukla D
影响因子：
6.4
作者：
Liu CM;Hungate BA;Tobian AA;Ravel J;Prodger JL;Serwadda D;Kigozi G;Galiwango RM;Nalugoda F;Keim P;Wawer MJ;Price LB;Gray RH
通讯作者：
Gray RH