Brain is an endocrine organ through secretion and nuclear transfer of parathymosin.
Brain is an endocrine organ through secretion and nuclear transfer of parathymosin.
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DOI：
10.26508/lsa.202000917
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发表时间：
2020-12
影响因子：
4.4
通讯作者：
Cai D
中科院分区：
文献类型：
--
作者：
Yu B;Tang Y;Cai D
The hypothalamus and brain neurons orchestrate the secretion and nuclear transfer of PTMS which is neuroprotective against aging-related disorders. This study reports that parathymosin (PTMS) is secreted by hypothalamic stem/progenitor cells (htNSC) to inhibit senescence of recipient cells such as fibroblasts. Upon release, PTMS is rapidly transferred into the nuclei of various cell types, including neuronal GT1-7 cells and different peripheral cells, and it is effectively transferred into neuronal nuclei in various brain regions in vivo. Notably, brain neurons also produce and release PTMS, and because neuronal populations are large, they are important for maintaining PTMS in the cerebrospinal fluid which is further transferable into the blood. Compared with several other brain regions, the hypothalamus is stronger for long-distance PTMS transfer, supporting a key hypothalamic role in this function. In physiology, aging is associated with declines in PTMS production and transfer in the brain, and ptms knockdown in the hypothalamus versus hippocampus were studied showing different contributions to neurobehavioral physiology. In conclusion, the brain is an endocrine organ through secretion and nuclear transfer of PTMS, and the hypothalamus–brain orchestration of this function is protective in physiology and counteractive against aging-related disorders.
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影响因子：
64.5
作者：
López-Otín C;Blasco MA;Partridge L;Serrano M;Kroemer G
通讯作者：
Kroemer G
剪接因子SRSF3的下调诱导p53β，p53β，一种p53的剪接同工型，可促进细胞衰老。
影响因子：
8
作者：
Tang Y;Horikawa I;Ajiro M;Robles AI;Fujita K;Mondal AM;Stauffer JK;Zheng ZM;Harris CC
通讯作者：
Harris CC
影响因子：
14.8
作者：
Leger, Marianne;Quiedeville, Anne;Freret, Thomas
通讯作者：
Freret, Thomas
影响因子：
3.9
作者：
CLINTON, M;FRANGOULAZARIDIS, M;HORECKER, BL
通讯作者：
HORECKER, BL
DOI：
10.1073/pnas.82.4.1050
发表时间：
1985-01-01
影响因子：
11.1
作者：
HARITOS, AA;SALVIN, SB;HORECKER, BL
通讯作者：
HORECKER, BL