In Vitro and in Vivo Characteristics of Fluorapatite-Forming Calcium Phosphate Cements.

In Vitro and in Vivo Characteristics of Fluorapatite-Forming Calcium Phosphate Cements.
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DOI:
10.6028/jres.115.020
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发表时间:
2010-07
影响因子:
1.5
通讯作者:
Ogiso B
Ogiso B
中科院分区:
工程技术4区
文献类型:
--
作者:
Takagi S;Frukhtbeyn S;Chow LC;Sugawara A;Fujikawa K;Ogata H;Hayashi M;Ogiso B

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本研究首次报道了形成氟磷灰石(FA)的磷酸钙骨水泥(CPC)的体内外特性。实验水泥含有(0-3.1)质量%的F,对应于FA的存在水平约为(0-87)质量%。随着FA含量的增加,磷灰石水泥制品的结晶度显著提高。大鼠皮下埋植后,随着FA含量的增加,体内吸收率显著降低。FA含量最高的水泥不会在软组织中被吸收,这使其成为第一个已知的生物相容性和生物惰性CPC。这些生物惰性CPC可能在需要缓慢或不需要种植体吸收才能达到预期临床结果的应用中有用。
This study reports for the first time in vitro and in vivo properties of fluorapatite (FA)-forming calcium phosphate cements (CPCs). The experimental cements contained from (0 to 3.1) mass % of F, corresponding to presence of FA at levels of approximately (0 to 87) mass %. The crystallinity of the apatitic cement product increased greatly with the FA content. When implanted subcutaneously in rats, the in vivo resorption rate decreased significantly with increasing FA content. The cement with the highest FA content was not resorbed in soft tissue, making it the first known biocompatible and bioinert CPC. These bioinert CPCs might be useful for applications where slow or no resorption of the implant is required to achieve the desired clinical outcome.
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