Increased lipid absorption and transport in the small intestine of zucker obese rats.
Increased lipid absorption and transport in the small intestine of zucker obese rats.
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DOI：
10.3164/jcbn.09-01
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发表时间：
2009-07
影响因子：
2.4
通讯作者：
Tso P
中科院分区：
文献类型：
--
作者：
Anzai K;Fukagawa K;Iwakiri R;Fujimoto K;Akashi K;Tso P
本研究的目的是比较Zucker肥胖大鼠和Spraogue-Dawley(SD)大鼠的肠道脂肪吸收能力。6只雄性Zucker肥胖症(FA/FA)和6只雄性SD大鼠裸露肠淋巴瘘。复苏24小时后，大鼠十二指肠内注入含40微克分子三油酸甘油酯、7.8微克分子磷脂酰胆碱和3毫升磷酸盐缓冲盐水的脂肪乳剂，速度为3毫升/小时，连续8小时，采集淋巴标本，测定放射性脂类含量。检测淋巴液载脂蛋白B(Apo B)水平。与SD大鼠相比，Zucker肥胖大鼠向淋巴中转运了更多的放射性脂质，尤其是在脂质吸收的早期阶段。肠粘膜淋巴载脂蛋白B水平较SD大鼠显著升高。总之，这项研究表明，Zucker肥胖大鼠的脂肪吸收和运输伴随着肠系膜淋巴中apo B水平的增加，表明脂肪吸收的增加可能至少在一定程度上与肥胖进展和高脂血症有关。
The aim of this study was to compare the potency of intestinal lipid absorption in Zucker obese rats compared with Sprague-Dawley (SD) rats. Six male Zucker obese (fa/fa) and six male SD rats baring intestinal lymph fistulae were used in this study. After 24 h recovery, rats were infused inraduodenally with a lipid emulsion containing 40 µmol triolein (labeled with glycerol tri[3H-oleate]), 7.8 µmol phosphatidyl choline in 3 ml phosphate buffered saline at a rate of 3 ml/h for 8 h. Lymph samples were collected and the radioactive lipid content determined. Apolipoprotein B (apo B) level in the lymph was evaluated. The Zucker obese rats transported more radioactive lipid into the lymph compared with the SD rats, particularly in the early phase of lipid absorption. Lymph apo B levels in the intestinal mucosa were significantly increased compared with the SD rats. In conclusion, this study indicated that lipid absorption and transport in Zucker obese rats is concomitant with increased apo B levels in the mesenteric lymph, indicating that the increase in lipid absorption may be responsible, at least in part, for obesity progression and hyperlipidemia.
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影响因子：
4.2
作者：
COMAI, K;TRISCARI, J;SULLIVAN, AC
通讯作者：
SULLIVAN, AC
影响因子：
--
作者：
SCHONFELD, G;PFLEGER, B
通讯作者：
PFLEGER, B
影响因子：
3.8
作者：
TSO, P;FUJIMOTO, K
通讯作者：
FUJIMOTO, K
DOI：
10.3181/00379727-215-44112
发表时间：
1997-05-01
影响因子：
--
作者：
Ogata, S;Fujimoto, K;Sakai, T
通讯作者：
Sakai, T
影响因子：
--
作者：
HAYASHI, H;FUJIMOTO, K;TSO, P
通讯作者：
TSO, P