Integrin, Exosome and Kidney Disease.
Integrin, Exosome and Kidney Disease.
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DOI：
10.3389/fphys.2020.627800
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发表时间：
2020
影响因子：
4
通讯作者：
Lv LL
中科院分区：
文献类型：
--
作者：
Shen AR;Zhong X;Tang TT;Wang C;Jing J;Liu BC;Lv LL
整合素是跨膜受体，其作为非共价异二聚体起作用，介导细胞粘附和迁移、细胞间通讯和细胞内信号传导激活。在肾脏，潜伏相关肽转化生长因子β（transforminggrowthfactor β，TGF-β）和可溶性尿激酶纤溶酶原激活物受体（solubleurokinaseplasminogenactivatorreceptor，suPAR）是整合素的新配体，参与肾间质纤维化和局灶节段性肾小球硬化（focalsegmentalglomerulosclerosis，FSGS）的形成。有趣的是，最近的研究表明，整合素是外来体的组成货物。越来越多的证据表明，外泌体整合素在肿瘤转移、神经系统疾病、免疫调节等多种病理生理过程中发挥着重要作用。本文将重点介绍外泌体整合素的生物学和功能，强调其在肾脏疾病中的潜在作用以及其在开发肾脏疾病新的治疗和诊断方法中的意义。
Integrins are transmembrane receptors that function as noncovalent heterodimers that mediate cellular adhesion and migration, cell to cell communication, and intracellular signaling activation. In kidney, latency associated peptide-transforming growth factor β (TGF-β) and soluble urokinase plasminogen activator receptor (suPAR) were found as the novel ligands of integrins that contribute to renal interstitial fibrosis and focal segmental glomerular sclerosis glomerulosclerosis (FSGS). Interestingly, recent studies revealed that integrins are the compositional cargo of exosomes. Increasing evidence suggested that exosomal integrin played critical roles in diverse pathophysiologic conditions such as tumor metastasis, neurological disorders, immunology regulation, and other processes. This review will focus on the biology and function of exosomal integrin, emphasizing its potential role in kidney disease as well as its implications in developing novel therapeutic and diagnosis approaches for kidney disease.
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DOI：
10.1126/science.aau6977
发表时间：
2020-02-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kalluri R;LeBleu VS
通讯作者：
LeBleu VS
影响因子：
82.9
作者：
Hayek SS;Koh KH;Grams ME;Wei C;Ko YA;Li J;Samelko B;Lee H;Dande RR;Lee HW;Hahm E;Peev V;Tracy M;Tardi NJ;Gupta V;Altintas MM;Garborcauskas G;Stojanovic N;Winkler CA;Lipkowitz MS;Tin A;Inker LA;Levey AS;Zeier M;Freedman BI;Kopp JB;Skorecki K;Coresh J;Quyyumi AA;Sever S;Reiser J
通讯作者：
Reiser J
影响因子：
4
作者：
De Franceschi N;Hamidi H;Alanko J;Sahgal P;Ivaska J
通讯作者：
Ivaska J
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
3.2
作者：
BREUSS, JM;GILLETT, N;PYTELA, R
通讯作者：
PYTELA, R