Mago, a vertebrate homolog of Drosophila Mago nashi protein, is a component of the chromatoid body in the cytoplasm of the postmeiotic spermatid.

Mago, a vertebrate homolog of Drosophila Mago nashi protein, is a component of the chromatoid body in the cytoplasm of the postmeiotic spermatid.
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Mago 是果蝇 Mago nashi 蛋白的脊椎动物同源物,是减数分裂后精子细胞细胞质中类染色质体的组成部分。

DOI:
10.1002/jez.b.21331
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发表时间:
2009-11
期刊:
Journal of experimental zoology. Part B, Molecular and developmental evolution
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其他
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转录后调节在脊椎动物精子发生过程中发挥着至关重要的作用。拟染色体(CB)是精子细胞中一种重要的细胞器,它被认为参与转录后过程,但其真实的功能尚不清楚。本文报道了从黄鳝中鉴定出的Mago基因,并对其进化保守性、在性腺转化过程中的差异表达和定位进行了研究。Mago与Y14相互作用,这可能有助于支持细胞中这两种蛋白质的核输出。重要的是,我们已经确定了Mago作为CB在发育中的精子细胞的细胞质中的新组分。将Mago添加到CB的组分列表中无疑为CB在脊椎动物精子发生中的功能提供了新的线索。
Post-transcriptional regulations play a crucial role during spermatogenesis of the vertebrates. Chromatoid body (CB) is a characteristic spermatid organelle that is supposed to exert its role in post-transcriptional processes, but its real functions remain largely unknown. Here we report identification of Mago from the rice field eel, and show its evolutionary conservation, differential expression and localization during gonadal transformation. The Mago interacts with Y14, which may facilitate nuclear export of both proteins in the Sertoli cells. Importantly, we have determined Mago as a novel component of the CB in the cytoplasm of the developing spermatid. Addition of Mago to the component list of the CB undoubtedly provides new clue as to the functions of the CB during spermatogenesis in the vertebrates.
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