The impact of obstructive sleep apnea on chronic kidney disease.
The impact of obstructive sleep apnea on chronic kidney disease.
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DOI：
10.1007/s11906-010-0135-1
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发表时间：
2010-10
影响因子：
5.6
通讯作者：
Rosas, Sylvia E.
中科院分区：
文献类型：
--
作者：
Adeseun, Gbemisola A.;Rosas, Sylvia E.
阻塞性睡眠呼吸暂停（OSA）是慢性肾脏病（CKD）人群中的一个重要临床问题。OSA与低氧血症和睡眠片段相关，其激活交感神经系统、肾素-血管紧张素-醛固酮系统，改变心血管血流动力学，并导致自由基产生。反过来，触发了多种有害过程，如内皮功能障碍、炎症、血小板聚集、动脉粥样硬化和纤维化，使个体易患不良心血管事件和可能的肾损伤。独立于肥胖，OSA与肾小球高滤过相关，可能是蛋白尿的独立预测因子，蛋白尿是CKD进展的危险因素。OSA还与高血压相关，高血压是CKD进展的另一个重要风险因素，特别是蛋白尿性CKD。OSA可能通过多种机制介导肾损伤，需要更好地阐明OSA对肾脏疾病和CKD进展的影响。
Obstructive sleep apnea (OSA) is an important clinical problem in the chronic kidney disease (CKD) population. OSA is associated with hypoxemia and sleep fragmentation, which activates the sympathetic nervous system, the renin-angiotensin-aldosterone system, alters cardiovascular hemodynamics, and results in free radical generation. In turn, a variety of deleterious processes such as endothelial dysfunction, inflammation, platelet aggregation, atherosclerosis, and fibrosis are triggered, predisposing individuals to adverse cardiovascular events and likely renal damage. Independent of obesity, OSA is associated with glomerular hyperfiltration and may be an independent predictor of proteinuria, a risk factor for CKD progression. OSA is also associated with hypertension, another important risk factor for CKD progression, particularly proteinuric CKD. OSA may mediate renal damage via several mechanisms, and there is a need to better elucidate the impact of OSA on incident renal disease and CKD progression.
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影响因子：
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