Impact of pregnancy on polyfunctional IgG and memory B cell responses to Tdap immunization.
Impact of pregnancy on polyfunctional IgG and memory B cell responses to Tdap immunization.
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妊娠对多功能 IgG 和记忆 B 细胞对 Tdap 免疫反应的影响。
DOI：
10.1016/j.vaccine.2023.05.035
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发表时间：
2023
期刊：
影响因子：
5.5
通讯作者：
Dauby,Nicolas
中科院分区：
文献类型：
--
作者：
Taton,Martin;Willems,Fabienne;Widomski,Cyprien;Martin,Charlotte;Jiang,Yiwei;Renard,Katty;Cogan,Alexandra;Necsoi,Coca;Ackerman,MargaretE;Marchant,Arnaud;Dauby,Nicolas
背景许多国家推荐使用Tdap疫苗进行母亲百日咳免疫，以保护新生儿免受严重的出生后感染。怀孕期间的免疫变化可能会影响对疫苗的反应。IgG和记忆B细胞的反应，以Tdap免疫在孕妇的质量尚未被描述。MethodsThe怀孕的影响，对Tdap疫苗接种的反应进行了评估，通过比较体液免疫反应在42个怀孕和39个非怀孕的妇女。血清百日咳抗原和破伤风类毒素特异性IgG，IgG亚类，IgG Fc介导的效应子功能，以及记忆B细胞频率的水平进行了评估之前，并在几个时间点后vaccination.ResultsTdap免疫诱导类似水平的百日咳和破伤风特异性IgG和IgG亚类在孕妇和非孕妇。孕妇产生的IgG促进补体沉积，中性粒细胞和巨噬细胞吞噬作用的水平与非孕妇相当。她们也能够以与非怀孕妇女相似的频率扩增百日咳和破伤风特异性记忆B细胞，这表明了等效的“可增强性”。与母血相比，在脐带血中检测到更高水平的疫苗特异性IgG、IgG亚类和IgG Fc介导的效应子功能，结论本研究表明，妊娠不会影响效应IgG和记忆B细胞对Tdap免疫的应答质量，并且多功能IgG可以有效地通过胎盘转运。numberClinicalTrials.Gov（NCT 03519373）。
BackgroundMaternal pertussis immunization using Tdap vaccine is recommended in many countries to protect newborns from severe post-natal infection. Immunological changes during pregnancy may influence the response to vaccines. The quality of IgG and memory B cell responses to Tdap immunization in pregnant women has not yet been described.MethodsThe impact of pregnancy on the response to Tdap vaccination was assessed by comparing humoral immune responses in 42 pregnant and 39 non-pregnant women. The levels of serum pertussis antigens and tetanus toxoid-specific IgG, IgG subclasses, IgG Fc-mediated effector functions, as well as memory B cell frequencies were assessed before and at several time points after vaccination.ResultsTdap immunization induced similar levels of pertussis and tetanus-specific IgG and IgG subclasses in pregnant and non-pregnant women. Pregnant women produced IgG promoting complement deposition, and neutrophils and macrophages phagocytosis at levels comparable to non-pregnant women. They were also able to expand pertussis and tetanus-specific memory B cells at similar frequencies as non-pregnant women, suggesting equivalent “boostability”. Higher levels of vaccine-specific IgG, IgG subclasses, and IgG Fc-mediated effector functions were detected in cord blood as compared to maternal blood, indicating efficient transport across the placenta.ConclusionsThis study demonstrates that pregnancy does not affect the quality of effector IgG and memory B cell responses to Tdap immunization and that polyfunctional IgG are efficiently transferred across the placenta.Registry's URL and the trial's registration numberClinicalTrials.Gov (NCT03519373).
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原发性人巨细胞病毒感染期间效应记忆 B 细胞对包膜糖蛋白 B 的反应有限。
DOI：
10.1093/infdis/jiv769
发表时间：
2016
期刊：
The Journal of infectious diseases
影响因子：
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作者：
N. Dauby;D. Sartori;C. Kummert;S. Lecomte;E. Haelterman;M. Delforge;C. Donner;M. Mach;A. Marchant
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影响因子：
5.5
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Leuridan, Elke
影响因子：
5.5
作者：
Barkoff, Alex-Mikael;Grondahl-Yli-Hannuksela, Kirsi;He, Qiushui
通讯作者：
He, Qiushui
影响因子：
5.5
作者：
Maertens, Kirsten;Cabore, Raissa Nadege;Leuridan, Elke
通讯作者：
Leuridan, Elke