Evaluation of Anti-PT Antibody Response after Pertussis Vaccination and Infection: The Importance of Both Quantity and Quality.
Evaluation of Anti-PT Antibody Response after Pertussis Vaccination and Infection: The Importance of Both Quantity and Quality.
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DOI：
10.3390/toxins13080508
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发表时间：
2021-07-21
期刊：
影响因子：
4.2
通讯作者：
He Q
中科院分区：
文献类型：
--
作者：
Barkoff AM;Knuutila A;Mertsola J;He Q
百日咳毒素（PT）被认为是导致百日咳或百日咳的主要毒力因素。该蛋白被广泛研究，其组成在20世纪80年代已被揭示和测序。人体免疫系统产生良好的反应，对PT量的测量。然而，血清抗pt抗体衰减迅速，在接种/感染后几年内仅发现少量抗体。因此，已经研究了多种方法来研究这些抗体的功能（质量），例如，亲和力，中和能力和表位特异性。此外，B细胞对PT的长期记忆（Bmem）对整个生命的良好保护至关重要。本文综述了功能性PT抗体和Bmem的研究结果。这些结果与血清抗pt抗体的数量一致。PT中和抗体和抗PT抗体具有适当的亲和力，对于良好的疾病保护至关重要，并且某些表位已被确定在保护中具有多种功能。尽管在疫苗接种后至少5年可检测到pt特异性Bmem反应，但缺乏长期监测。在这些记忆研究中，社区中循环百日咳杆菌自然增强的变化是一个重要的混杂因素。
Pertussis toxin (PT) is considered the main virulence factor causing whooping cough or pertussis. The protein is widely studied and its composition was revealed and sequenced already during the 1980s. The human immune system creates a good response against PT when measured in quantity. However, the serum anti-PT antibodies wane rapidly, and only a small amount of these antibodies are found a few years after vaccination/infection. Therefore, multiple approaches to study the functionality (quality) of these antibodies, e.g., avidity, neutralizing capacity, and epitope specificity, have been investigated. In addition, the long-term B cell memory (Bmem) to PT is crucial for good protection throughout life. In this review, we summarize the findings from functional PT antibody and Bmem studies. These results are discussed in line with the quantity of serum anti-PT antibodies. PT neutralizing antibodies and anti-PT antibodies with proper avidity are crucial for good protection against the disease, and certain epitopes have been identified to have multiple functions in the protection. Although PT-specific Bmem responses are detectable at least five years after vaccination, long-term surveillance is lacking. Variation of the natural boosting of circulating Bordetella pertussis in communities is an important confounding factor in these memory studies.
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DOI：
10.1111/j.1600-0463.2010.02664.x
发表时间：
2010-12
期刊：
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
影响因子：
--
作者：
Dalby T;Sørensen C;Petersen JW;Krogfelt KA
通讯作者：
Krogfelt KA
影响因子：
64.5
作者：
BEREK, C;BERGER, A;APEL, M
通讯作者：
APEL, M
影响因子：
--
作者：
Aase, Audun;Herstad, Tove Karin;Aaberge, Ingeborg S.
通讯作者：
Aaberge, Ingeborg S.
影响因子：
19
作者：
Dalby, T.;Andersen, P. H.;Hoffmann, S.
通讯作者：
Hoffmann, S.
影响因子：
3.6
作者：
Carlsson, RM;Claesson, BA;Lundin, C
通讯作者：
Lundin, C