Calcium plus vitamin D supplementation and lung cancer incidence among postmenopausal women in the Women's Health Initiative.
Calcium plus vitamin D supplementation and lung cancer incidence among postmenopausal women in the Women's Health Initiative.
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DOI：
10.1016/j.lungcan.2017.06.002
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Wactawski-Wende J
中科院分区：
文献类型：
--
作者：
Tao MH;Dai Q;Chen S;Freudenheim JL;Rohan T;Wakelee H;Datta M;Wactawski-Wende J
镁和钙在许多生理过程中是拮抗的。然而，很少有研究调查补充钙与肺癌风险的关联，考虑到这种拮抗作用。我们评估了钙和维生素D补充剂对肺癌发病率的影响，并探讨了基线钙镁（Ca：Mg）摄入量的比例是否改变了妇女健康倡议（WHI）钙加维生素D补充剂（CaD）试验中的相关性。WHI CaD的干预阶段是一项双盲、随机、安慰剂对照试验，在40个美国中心招募了36，382名50-79岁的绝经后妇女。在29，862名（86%）幸存参与者中继续进行干预后随访。使用比例风险回归模型评估了与补充CaD相关的肺癌风险。经过11年的累积随访，补充剂组有207例肺癌（每年发病率0.11%），安慰剂组有241例（0.12%）（干预的风险比（HR）为0.91; 95%置信区间（CI）为0.71-1.17）。亚组分析表明，在入组时为当前吸烟者的女性中，肺癌的HR因基线Ca：Mg摄入比例而异（相互作用p = 0.04）。在整个随访期间，钙和维生素D补充剂并没有降低绝经后妇女的肺癌发病率。在探索性分析中，发现在试验入组时，当前吸烟者中基线钙：镁摄入比例与肺癌存在相互作用。这一发现需要进一步研究钙镁在当前吸烟者肺癌发生中的作用。
Magnesium and calcium are antagonistic in many physiologic processes. However, few studies have investigated the associations of supplemental calcium with lung cancer risk taking this antagonism into account. We evaluated the effect of calcium and vitamin D supplementation on lung cancer incidence and explored whether the ratio of baseline calcium to magnesium (Ca:Mg) intake modifies the association in the Women’s Health Initiative (WHI) calcium plus vitamin D supplementation (CaD) trial. The intervention phase of the WHI CaD was a double-blinded, randomized, placebo-controlled trial in 36,382 postmenopausal women aged 50–79 years, recruited at 40 U.S. centers. Post-intervention follow-up continued among 29,862 (86%) of the surviving participants. Risk of lung cancer in association with CaD supplementation was evaluated using proportional hazard regression models. After 11 years’ cumulative follow-up, there were 207 lung cancers (incidence 0.11% per year) in the supplement arm and 241 (0.12%) in the placebo arm (hazard ratio (HR) for the intervention, 0.91; 95% confidence interval (CI), 0.71–1.17). Subgroup analyses suggested that the HR for lung cancer varied by baseline Ca:Mg intake ratio among women who were current smokers at enrollment (p = 0.04 for interaction). Over the entire follow-up period, calcium and vitamin D supplementation did not reduce lung cancer incidence among postmenopausal women. In exploratory analyses, an interaction was found for the baseline Ca:Mg intake ratio on lung cancer among current smokers at the trial entry. This findings need to be further studied for the role of calcium with magnesium in lung carcinogenesis in current smokers.
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影响因子：
4.4
作者：
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通讯作者：
Brinkmeier, Heinrich
影响因子：
2.9
作者：
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通讯作者：
Zheng W
影响因子：
5
作者：
Bussière, FI;Gueux, E;Rayssiguier, Y
通讯作者：
Rayssiguier, Y
影响因子：
13.6
作者：
Groenestege, Wouter M. Tiel;Hoenderop, Joost G.;Bindels, Rene J.
通讯作者：
Bindels, Rene J.
DOI：
10.1158/1055-9965.epi-10-0067
发表时间：
2010-08
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Mahabir S;Forman MR;Dong YQ;Park Y;Hollenbeck A;Schatzkin A
通讯作者：
Schatzkin A