Global reemergence of enterovirus D68 as an important pathogen for acute respiratory infections.
Global reemergence of enterovirus D68 as an important pathogen for acute respiratory infections.
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DOI：
10.1002/rmv.1820
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发表时间：
2015-03
影响因子：
11.1
通讯作者：
Oshitani, Hitoshi
中科院分区：
文献类型：
--
作者：
Imamura, Tadatsugu;Oshitani, Hitoshi
我们之前在2008-2009年菲律宾严重急性呼吸道感染儿童中检测到肠道病毒D 68（EV-D 68）。从那时起，EV-D 68的检测频率在世界不同地区有所增加，EV-D 68现在被认为是一种重新出现的病原体。然而，EV-D 68的流行病学特征和临床意义尚未确定，EV-D 68的病毒学特征尚未完全了解。最近的研究表明，EV-D 68在患有不同严重程度的急性呼吸道感染的患者中检测到，从轻度上呼吸道感染到严重肺炎，包括儿童和成人患者的致命病例。在一些研究中心，下呼吸道感染患者的EV-D 68检出率高于上呼吸道感染患者，表明EV-D 68感染更可能与严重呼吸道疾病相关。近年来流行的EV-D 68毒株分为三个不同的遗传谱系，具有不同的抗原性。然而，遗传差异与疾病严重程度以及大规模疫情发生之间的关联仍然难以捉摸。先前的研究表明，EV-D 68对酸敏感，最佳生长温度为33 °C。EV-D 68与α 2，6-连接的唾液酸结合;因此，假定其对存在这些聚糖的上呼吸道具有亲和力。然而，缺乏合适的动物模型限制了对EV-D 68发病机制的全面了解。© 2014作者。出版社：John Wiley & Sons Ltd.
We previously detected enterovirus D68 (EV-D68) in children with severe acute respiratory infections in the Philippines in 2008–2009. Since then, the detection frequency of EV-D68 has increased in different parts of the world, and EV-D68 is now recognized as a reemerging pathogen. However, the epidemiological profile and clinical significance of EV-D68 is yet to be defined, and the virological characteristics of EV-D68 are not fully understood. Recent studies have revealed that EV-D68 is detected among patients with acute respiratory infections of differing severities ranging from mild upper respiratory tract infections to severe pneumonia including fatal cases in pediatric and adult patients. In some study sites, the EV-D68 detection rate was higher among patients with lower respiratory tract infections than among those with upper respiratory tract infections, suggesting that EV-D68 infections are more likely to be associated with severe respiratory illnesses. EV-D68 strains circulating in recent years have been divided into three distinct genetic lineages with different antigenicity. However, the association between genetic differences and disease severity, as well as the occurrence of large-scale outbreaks, remains elusive. Previous studies have revealed that EV-D68 is acid sensitive and has an optimal growth temperature of 33 °C. EV-D68 binds to α2,6-linked sialic acids; hence, it is assumed that it has an affinity for the upper respiratory track where these glycans are present. However, the lack of suitable animal model constrains comprehensive understanding of the pathogenesis of EV-D68. © 2014 The Authors. Reviews in Medical Virology published by John Wiley & Sons Ltd.
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