Cryogenic Exfoliation of 2D Stanene Nanosheets for Cancer Theranostics.
Cryogenic Exfoliation of 2D Stanene Nanosheets for Cancer Theranostics.
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DOI：
10.1007/s40820-021-00619-1
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发表时间：
2021-03-10
影响因子：
26.6
通讯作者：
Tao W
中科院分区：
文献类型：
--
作者：
Ouyang J;Zhang L;Li L;Chen W;Tang Z;Ji X;Feng C;Tao N;Kong N;Chen T;Liu YN;Tao W
采用低温剥离和液相剥离相结合的方法制备了二维锡纳米片。功能化的二维snns具有良好的稳定性、优越的生物相容性、较高的光热转换效率和多模成像能力。在线版本包含补充材料，可在10.1007/s40820-021-00619-1获得。锡基材料在工业生产和日常生活中得到了广泛的应用，但由于缺乏合适和有效的制备方法，其潜在的生物医学应用仍未得到充分的开发。在此，我们探索了一种结合低温剥离和液相剥离的新方法来成功制备二维（2D）锡纳米片（SnNSs）。所得SnNSs具有典型的片状结构，平均尺寸为~ 100 nm，厚度为~ 5.1 nm。聚乙二醇化后得到的SnNSs （SnNSs@PEG）具有良好的稳定性、优越的生物相容性和优异的光热性能，可作为多模态成像（荧光/光声/光热成像）引导的光热消除癌症的强大光热剂。此外，我们还利用第一性原理密度泛函理论计算研究了SnNSs的光热机制，揭示了SnNSs上层和下层的自由电子有助于光到热的转换。本工作不仅介绍了一种制备二维SnNSs的新方法，而且建立了用于光子癌症治疗的基于SnNSs的纳米药物。这种新型SnNSs在纳米医学领域具有巨大的潜力，可能会掀起一股开发锡基生物材料的浪潮，造福于生物医学应用。在线版本包含补充材料，可在10.1007/s40820-021-00619-1获得。
2D Sn nanosheets (SnNSs) were prepared through the combination of cryogenic exfoliation and liquid-phase exfoliation. The functionalized 2D SnNSs have good stability, superior biocompatibility, high photothermal conversion efficiency, and multimode imaging capability. The online version contains supplementary material available at 10.1007/s40820-021-00619-1. Stanene (Sn)-based materials have been extensively applied in industrial production and daily life, but their potential biomedical application remains largely unexplored, which is due to the absence of the appropriate and effective methods for fabricating Sn-based biomaterials. Herein, we explored a new approach combining cryogenic exfoliation and liquid-phase exfoliation to successfully manufacture two-dimensional (2D) Sn nanosheets (SnNSs). The obtained SnNSs exhibited a typical sheet-like structure with an average size of ~ 100 nm and a thickness of ~ 5.1 nm. After PEGylation, the resulting PEGylated SnNSs (SnNSs@PEG) exhibited good stability, superior biocompatibility, and excellent photothermal performance, which could serve as robust photothermal agents for multi-modal imaging (fluorescence/photoacoustic/photothermal imaging)-guided photothermal elimination of cancer. Furthermore, we also used first-principles density functional theory calculations to investigate the photothermal mechanism of SnNSs, revealing that the free electrons in upper and lower layers of SnNSs contribute to the conversion of the photo to thermal. This work not only introduces a new approach to fabricate 2D SnNSs but also establishes the SnNSs-based nanomedicines for photonic cancer theranostics. This new type of SnNSs with great potential in the field of nanomedicines may spur a wave of developing Sn-based biological materials to benefit biomedical applications. The online version contains supplementary material available at 10.1007/s40820-021-00619-1.
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