Relationships between body composition and pulmonary function in a community-dwelling population in Japan.
Relationships between body composition and pulmonary function in a community-dwelling population in Japan.
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DOI：
10.1371/journal.pone.0242308
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Nakaji S
中科院分区：
文献类型：
--
作者：
Kawabata R;Soma Y;Kudo Y;Yokoyama J;Shimizu H;Akaike A;Suzuki D;Katsuragi Y;Totsuka M;Nakaji S
包括慢性阻塞性肺病（COPD）在内的肺部疾病是导致肺功能下降的主要慢性疾病。身体成分和肺功能之间的关系已经报道。然而，很少有流行病学研究使用内脏脂肪面积（VFA）来衡量身体成分。本研究旨在探讨身体成分与肺功能之间的关系。2015年至2016年期间，对居住在日本青森县农村地区广崎市岩城地区的1，287名年龄在19至91岁之间的居民进行了横断面研究。采用用力肺活量（FVC）占预测值的百分比（预测FVC%）和1秒用力呼气量（FEV 1）与FVC的比值评价肺功能。评价体成分的指标包括全身和躯干的体脂百分比（BFP）、骨骼肌指数（SMI）、体重指数（BMI）、VFA、肚脐水平的腰围（WC）和腰臀比（WHR）。为了校正潜在的混杂因素，采用斯皮尔曼偏相关分析来检查身体成分和肺功能测量值之间的关系。FVC%预测值与以下参数之间存在显著相关性：年轻男性的BFP（全身和躯干）;老年男性的SMI;年轻女性的WC、VFA、BMI和SMI;老年女性的BFP（全身和躯干）和VFA。相反，年轻男性的WC和VFA以及年轻女性的WC与FEV 1/FVC比值相关。在年轻男性中，VFA与FEV 1/FVC比值相关，在老年女性中，VFA与FVC%预测值相关。这些结果表明，内脏脂肪蓄积可能会增加年轻男性阻塞性肺疾病的发生，并加速老年女性肺功能（预测FVC%）的下降。
Pulmonary diseases, including chronic obstructive pulmonary disease (COPD), are major chronic diseases that result in decreased pulmonary function. Relationships between body composition and pulmonary function have been reported. However, few epidemiological studies have used the visceral fat area (VFA) to measure body composition. This study aimed to examine the relationship between body composition and pulmonary function. A cross-sectional study was conducted between 2015 and 2016, using data obtained from 1,287 residents aged between 19 and 91 years living in the Iwaki area of Hirosaki City, a rural region in Aomori Prefecture, Japan. Pulmonary function was evaluated using the forced vital capacity (FVC) as a percentage of the predicted value (predicted FVC%) and the ratio of forced expiratory volume in one second (FEV1) to FVC. The measurements for evaluating body composition included the body fat percentage (BFP) of the whole body and trunk, skeletal muscle index (SMI), body mass index (BMI), VFA, waist circumference (WC) at the navel level, and waist-to-hip ratio (WHR). To adjust for potential confounders, Spearman’s partial correlation analysis was used to examine the relationship between the measurements of body composition and pulmonary function. There were significant correlations between the predicted FVC% and the following parameters: BFP (whole body and trunk) in younger males; SMI in older males; WC, VFA, BMI, and SMI in younger females; and BFP (whole body and trunk) and VFA in older females. Contrastingly, WC and VFA in younger males and WC in younger females were correlated with the FEV1/FVC ratio. VFA was correlated with the FEV1/FVC ratio in younger males and predicted FVC% in older females. These findings suggest that visceral fat accumulation may increase the development of obstructive pulmonary disease in young males and accelerate the decline of pulmonary function (predicted FVC%) in older females.
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