Repeated exposure of adult rats to transient oxidative stress induces various long-lasting alterations in cognitive and behavioral functions.
Repeated exposure of adult rats to transient oxidative stress induces various long-lasting alterations in cognitive and behavioral functions.
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DOI：
10.1371/journal.pone.0114024
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Toda S
中科院分区：
文献类型：
--
作者：
Iguchi Y;Kosugi S;Nishikawa H;Lin Z;Minabe Y;Toda S
新生儿暴露于氧化应激可能会增加精神疾病的风险，如成年后的精神分裂症。然而，适度的氧化应激对成人大脑的影响还没有完全了解。为了解决这个问题，我们全身给予2-环己烯-1-酮（CHX）的成年大鼠短暂降低谷胱甘肽水平。重复给药的CHX不影响收购或动机的食欲工具性行为（杠杆按下）奖励的食物结果下的累进比例计划。此外，反应辨别和逆转学习也没有受到影响。然而，急性CHX管理钝化的敏感性，结果贬值的工具性能，这种效果是长期在大鼠的历史反复CHX暴露，代表亲抑郁样表型。另一方面，重复给予CHX可减少强迫游泳试验中的不动性，并使急性可卡因诱导的行为变钝，这表明其具有抗抑郁样作用。多变量分析分离出一组受CHX重复给药影响的特征性行为变量。总之，这些发现表明，对成年大鼠重复给予CHX不会引起特定的精神障碍，但它会诱导行为和认知功能的长期改变，可能与特定的神经相关性有关。
Exposure of neonates to oxidative stress may increase the risk of psychiatric disorders such as schizophrenia in adulthood. However, the effects of moderate oxidative stress on the adult brain are not completely understood. To address this issue, we systemically administrated 2-cyclohexen-1-one (CHX) to adult rats to transiently reduce glutathione levels. Repeated administration of CHX did not affect the acquisition or motivation of an appetitive instrumental behavior (lever pressing) rewarded by a food outcome under a progressive ratio schedule. In addition, response discrimination and reversal learning were not affected. However, acute CHX administration blunted the sensitivity of the instrumental performance to outcome devaluation, and this effect was prolonged in rats with a history of repeated CHX exposure, representing pro-depression-like phenotypes. On the other hand, repeated CHX administration reduced immobility in forced swimming tests and blunted acute cocaine-induced behaviors, implicating antidepressant-like effects. Multivariate analyses segregated a characteristic group of behavioral variables influenced by repeated CHX administration. Taken together, these findings suggest that repeated administration of CHX to adult rats did not cause a specific mental disorder, but it induced long-term alterations in behavioral and cognitive functions, possibly related to specific neural correlates.
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影响因子：
34.7
作者：
Arnsten, Amy F. T.
通讯作者：
Arnsten, Amy F. T.
影响因子：
6.9
作者：
Emiliani FE;Sedlak TW;Sawa A
通讯作者：
Sawa A
DOI：
10.1037/0097-7403.30.2.104
发表时间：
2004-04-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIORAL PROCESSES
影响因子：
--
作者：
Holland, PC
通讯作者：
Holland, PC
影响因子：
2.9
作者：
ASHER, IM;AGHAJANIAN, GK
通讯作者：
AGHAJANIAN, GK
影响因子：
2.9
作者：
KELLY, PH;SEVIOUR, PW;IVERSEN, SD
通讯作者：
IVERSEN, SD