Endostatin/collagen XVIII is increased in cerebrospinal fluid after severe traumatic brain injury.
Endostatin/collagen XVIII is increased in cerebrospinal fluid after severe traumatic brain injury.
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DOI：
10.1155/2013/402375
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发表时间：
2013
影响因子：
--
通讯作者：
Tian HL
中科院分区：
文献类型：
--
作者：
Chen H;Xue LX;Cao HL;Chen SW;Guo Y;Gao WW;Ju SM;Tian HL
最近的研究表明，内源性血管生成抑制剂内皮抑素/XVIII 胶原蛋白可能在创伤性脑损伤（TBI）后的继发性脑损伤中发挥重要作用。在这项研究中，我们采用酶联免疫吸附测定法连续测量了 30 名入院时格拉斯哥昏迷量表 (GCS) 评分为 8 或以下的 TBI 患者的脑脊液 (CSF) 中的内皮抑素/XVIII 胶原蛋白浓度，持续 1 周。从损伤后 72 小时开始，与对照组相比，TBI 后 CSF 内皮抑素水平有显着增加的趋势。 GCS评分为3~5分的患者，伤后72小时脑脊液内皮抑素浓度显着高于GCS评分为6~8分的患者（P < 0.05），并在伤后第5天迅速达到峰值，但随后下降。创伤后第5天（P = 0.043）和第7天（P = 0.005）时，12名预后不良患者的脑脊液内皮抑素浓度显着高于18名预后良好的患者。受试者工作特征曲线分析表明，预测不良预后的 7 天脑脊液内皮抑素浓度的可靠工作点为 67.29pg/mL。我们的初步研究结果提供了新的证据，表明 sTBI 患者脑脊液中的内皮抑素/XVIII 胶原蛋白浓度大幅增加。其动态变化可能对判断脑损伤严重程度和评估预后具有一定的临床意义。该试验已在 ClinicalTrials.gov 上注册，标识符为：NCT01846546。
Recent studies have suggested that endogenous angiogenesis inhibitor endostatin/collagen XVIII might play an important role in the secondary brain injury following traumatic brain injury (TBI). In this study, we measured endostatin/collagen XVIII concentrations serially for 1 week after hospitalization by using the enzyme-linked immunosorbent assay method in the cerebrospinal fluid (CSF) of 30 patients with TBI and a Glasgow Coma Scale (GCS) score of 8 or less on admission. There was a significant trend toward increased CSF levels of endostatin after TBI versus control from 72 h after injury. In patients with GCS score of 3–5, CSF endostatin concentration was substantially higher at 72 h after injury than that in patients with GCS score of 6–8 (P < 0.05) and peaked rapidly at day 5 after injury, but decreased thereafter. The CSF endostatin concentration in 12 patients with an unfavorable outcome was significantly higher than that in 18 patients with a favorable outcome at day 5 (P = 0.043) and day 7 (P = 0.005) after trauma. Receiver operating characteristic curve analysis suggested a reliable operating point for the 7-day CSF endostatin concentration predicting poor prognosis to be 67.29 pg/mL. Our preliminary findings provide new evidence that endostatin/collagen XVIII concentration in the CSF increases substantially in patients with sTBI. Its dynamic change may have some clinical significance on the judgment of brain injury severity and the assessment of prognosis. This trial is registered with the ClinicalTrials.gov Identifier: NCT01846546.
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影响因子：
3.4
作者：
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通讯作者：
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DOI：
10.1097/ta.0b013e31821ac9e1
发表时间：
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影响因子：
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影响因子：
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作者：
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