Amniotic fluid from healthy term pregnancies does not harbor a detectable microbial community.
Amniotic fluid from healthy term pregnancies does not harbor a detectable microbial community.
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DOI：
10.1186/s40168-018-0475-7
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发表时间：
2018-05-11
期刊：
影响因子：
15.5
通讯作者：
Holtz LR
中科院分区：
文献类型：
--
作者：
Lim ES;Rodriguez C;Holtz LR
最近的研究对羊膜内微生物群的存在有相互矛盾的数据。病毒群落越来越被认为是人类微生物群中重要但被忽视的组成部分。尚不清楚发育中的胎儿是否暴露于病毒群落（病毒组）。鉴于对羊膜内微生物群落存在的争论以及了解婴儿肠道如何填充的重要性，我们使用下一代测序方法对24例无并发症足月妊娠的羊水中的病毒组和细菌微生物群进行了表征。与预期相反，羊水的细菌微生物群与污染对照没有区别。羊水中的病毒读数很少，我们没有发现样本中存在核心病毒群落的证据。本文的在线版本（10.1186/s40168-018-0475-7）包含补充材料，可供授权用户使用。
Recent studies have conflicting data regarding the presence of intra-amniotic microbiota. Viral communities are increasingly recognized as important although overlooked components of the human microbiota. It is unknown if the developing fetus is exposed to a community of viruses (virome). Given the debate over the existence of an intra-amniotic microbial community and the importance of understanding how the infant gut is populated, we characterized the virome and bacterial microbiota of amniotic fluid from 24 uncomplicated term pregnancies using next-generation sequencing methods. Contrary to expectations, the bacterial microbiota of amniotic fluid was indistinguishable from contamination controls. Viral reads were sparse in the amniotic fluid, and we found no evidence of a core viral community across samples. The online version of this article (10.1186/s40168-018-0475-7) contains supplementary material, which is available to authorized users.
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作者：
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发表时间：
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