Peripheral telomere length and hippocampal volume in adolescents with major depressive disorder.
Peripheral telomere length and hippocampal volume in adolescents with major depressive disorder.
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DOI：
10.1038/tp.2015.172
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发表时间：
2015-11-10
影响因子：
6.8
通讯作者：
Yang TT
中科院分区：
文献类型：
--
作者：
Henje Blom E;Han LK;Connolly CG;Ho TC;Lin J;LeWinn KZ;Simmons AN;Sacchet MD;Mobayed N;Luna ME;Paulus M;Epel ES;Blackburn EH;Wolkowitz OM;Yang TT
几项研究报告说，成年抑郁症患者的端粒长度较短，海马体积减小。此外，对没有重度抑郁症的成年人群的研究表明，外周端粒长度和海马体积之间存在关系。然而，这些发现与青少年抑郁症的关系还有待探讨。我们研究了青少年重性抑郁症是否与外周端粒长度和海马体积的改变有关，以及这些指标是否相互关联。在54名未服药的青少年（13-18岁）重度抑郁症和63名匹配良好的健康对照者中，使用定量聚合酶链反应方法从唾液中评估端粒长度，并用磁共振成像测量双侧海马体积。在调整年龄和性别（以及海马分析中的总脑体积）后，患有重度抑郁症的青少年表现出端粒长度显着更短，右侧海马体积显着更小，但左侧海马体积则不显着。当校正年龄，性别，诊断组和总脑容量，端粒长度与左或右海马体积没有显着相关性，这表明这些细胞和神经过程可能是在青春期的机械不同。我们的研究结果表明，端粒长度的缩短和海马体积的减少已经存在于早发性抑郁症，因此不太可能只是多年积累的结果暴露于抑郁症。
Several studies have reported that adults with major depressive disorder have shorter telomere length and reduced hippocampal volumes. Moreover, studies of adult populations without major depressive disorder suggest a relationship between peripheral telomere length and hippocampal volume. However, the relationship of these findings in adolescents with major depressive disorder has yet to be explored. We examined whether adolescent major depressive disorder is associated with altered peripheral telomere length and hippocampal volume, and whether these measures relate to one another. In 54 unmedicated adolescents (13–18 years) with major depressive disorder and 63 well-matched healthy controls, telomere length was assessed from saliva using quantitative polymerase chain reaction methods, and bilateral hippocampal volumes were measured with magnetic resonance imaging. After adjusting for age and sex (and total brain volume in the hippocampal analysis), adolescents with major depressive disorder exhibited significantly shorter telomere length and significantly smaller right, but not left hippocampal volume. When corrected for age, sex, diagnostic group and total brain volume, telomere length was not significantly associated with left or right hippocampal volume, suggesting that these cellular and neural processes may be mechanistically distinct during adolescence. Our findings suggest that shortening of telomere length and reduction of hippocampal volume are already present in early-onset major depressive disorder and thus unlikely to be only a result of accumulated years of exposure to major depressive disorder.
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影响因子：
3.7
作者：
Grodstein, Francine;van Oijen, Marieke;Irizarry, Michael C.;Rosas, H. Diana;Hyman, Bradley T.;Growdon, John H.;De Vivo, Immaculata
通讯作者：
De Vivo, Immaculata
DOI：
10.1038/nrg3246
发表时间：
2012-10
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
通讯作者：
--
影响因子：
15.1
作者：
Garcia-Rizo, Clemente;Fernandez-Egea, Emilio;Kirkpatrick, Brian
通讯作者：
Kirkpatrick, Brian
DOI：
10.1097/00004583-199703000-00012
发表时间：
1997-03-01
影响因子：
13.3
作者：
Bernstein, DP;Ahluvalia, T;Handelsman, L
通讯作者：
Handelsman, L
影响因子：
9.8
作者：
Entringer, Sonja;Epel, Elissa S.;Lin, Jue;Buss, Claudia;Shahbaba, Babak;Blackburn, Elizabeth H.;Simhan, Hyagriv N.;Wadhwa, Pathik D.
通讯作者：
Wadhwa, Pathik D.