Maternal psychosocial stress during pregnancy is associated with newborn leukocyte telomere length.
Maternal psychosocial stress during pregnancy is associated with newborn leukocyte telomere length.
复制标题
DOI：
10.1016/j.ajog.2012.11.033
复制
发表时间：
2013-02
影响因子：
9.8
通讯作者：
Wadhwa, Pathik D.
中科院分区：
文献类型：
--
作者：
Entringer, Sonja;Epel, Elissa S.;Lin, Jue;Buss, Claudia;Shahbaba, Babak;Blackburn, Elizabeth H.;Simhan, Hyagriv N.;Wadhwa, Pathik D.
关键词：
在成年人中，白细胞端粒长度（LTL）的主要决定因素之一，是与年龄有关的疾病和死亡率的预测因素，是累积的心理社会压力暴露。最近，我们报道，暴露于母亲的心理社会压力在宫内生活与LTL在年轻的成年。本研究的目的是确定如何在生命早期的压力对LTL的影响是明显的，通过量化的孕妇在怀孕期间的心理压力与新生儿端粒长度的关联。在一项N = 27对母亲-新生儿二联体的前瞻性研究中，在妊娠早期评估母亲妊娠特异性应激，随后收集脐带血外周血单核细胞并分析LTL测量。在考虑了新生儿LTL的潜在决定因素（出生时胎龄、体重、性别和产前产科并发症）的影响后，妊娠特异性应激对新生儿LTL有显著的、独立的、线性的影响，占调整后LTL方差的25%（β =-0.099; P = .04）。我们的发现提供了人类的第一个初步证据，即怀孕期间的母亲心理压力可能会对出生时已经明显的发育中的端粒生物学系统产生“编程”影响，正如新生儿LTL的设置所反映的那样。
In adults, one of the major determinants of leukocyte telomere length (LTL), a predictor of age-related diseases and mortality, is cumulative psychosocial stress exposure. More recently we reported that exposure to maternal psychosocial stress during intrauterine life is associated with LTL in young adulthood. The objective of the present study was to determine how early in life this effect of stress on LTL is apparent by quantifying the association of maternal psychosocial stress during pregnancy with newborn telomere length. In a prospective study of N = 27 mother-newborn dyads maternal pregnancy-specific stress was assessed in early gestation and cord blood peripheral blood mononuclear cells were subsequently collected and analyzed for LTL measurement. After accounting for the effects of potential determinants of newborn LTL (gestational age at birth, weight, sex, and exposure to antepartum obstetric complications), there was a significant, independent, linear effect of pregnancy-specific stress on newborn LTL that accounted for 25% of the variance in adjusted LTL (β = −0.099; P = .04). Our finding provides the first preliminary evidence in human beings that maternal psychological stress during pregnancy may exert a “programming” effect on the developing telomere biology system that is already apparent at birth, as reflected by the setting of newborn LTL.
登录
查看更多内容
影响因子：
11
作者：
Drury SS;Theall K;Gleason MM;Smyke AT;De Vivo I;Wong JY;Fox NA;Zeanah CH;Nelson CA
通讯作者：
Nelson CA
DOI：
10.1097/med.0b013e3283405921
发表时间：
2010-12
期刊：
Current opinion in endocrinology, diabetes, and obesity
影响因子：
--
作者：
Entringer S;Buss C;Wadhwa PD
通讯作者：
Wadhwa PD
DOI：
10.1111/j.1471-0528.2005.00839.x
发表时间：
2006-03-01
影响因子：
5.8
作者：
Akkad, A;Hastings, R;Williams, B
通讯作者：
Williams, B
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
14.9
作者：
Cawthon, RM
通讯作者：
Cawthon, RM