Response of infants to Haemophilus influenzae type b polysaccharide and diphtheria-tetanus-pertussis vaccines in combination.

Response of infants to Haemophilus influenzae type b polysaccharide and diphtheria-tetanus-pertussis vaccines in combination.
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婴儿对b型流感嗜血杆菌多糖和白喉-破伤风-百日咳联合疫苗的反应。

DOI:
10.1093/infdis/149.6.950
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发表时间:
1984
期刊:
The Journal of infectious diseases
影响因子:
--
通讯作者:
Lui,NS
Lui,NS
中科院分区:
--
文献类型:
--
作者:
Lepow,ML;Peter,G;Glode,MP;Daum,RS;Calnen,G;Knight,KM;Mayer,D;Kuo,JS;Lui,NS

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在一项多中心研究中,评价了107名婴儿对含有标准白喉-百日咳(DTP)和多聚核糖基核糖醇磷酸盐(PRP)(流感嗜血杆菌B型的荚膜多糖)的联合疫苗的反应,这些婴儿在2、4和6个月大时接受单次剂量,并与61名婴儿按相同时间表接受单次剂量DTP的反应进行比较。两个治疗组的反应率相当。在7个月大时,61%的接受联合DTP-PRP疫苗的受试者和8%的接受单独DTP的受试者显示出对PRP的抗体应答,定义为滴度比先前最低水平增加两倍。在接受DTP-PRP联合疫苗的患者中,92%的阳性抗体应答发生在第三剂之后。抗体应答存在差异,可能是由于接种的疫苗批次不同。
In a multicenter study, responses to a combined vaccine containing standard diphtheriatetanus-pertussis (DTP) and polyribosylribitol phosphate (PRP), the capsular polysaccharide ofHaemophilus influenzaetype b, were evaluated in 107 infants who received single doses at two, four, and six months of age and compared with those in 61 infants given single doses of DTP alone on the same schedule. Reaction rates were comparable in the two treatment groups. At seven months of age 61% of the subjects given the combined DTP-PRP vaccine and 8% and of those given DTP alone showed an antibody response to PRP, as defined as a twofold increase in titer over the lowest previous level. Among those given the DTP-PRP combined vaccine, 92% of the positive antibody responses occurred after the third dose. There was a variation in antibody response, possibly due to a difference in the vaccine lots administered.
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