Tender and swollen joint counts are poorly associated with disability in chikungunya arthritis compared to rheumatoid arthritis.
Tender and swollen joint counts are poorly associated with disability in chikungunya arthritis compared to rheumatoid arthritis.
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DOI：
10.1038/s41598-021-98164-9
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发表时间：
2021-09-17
影响因子：
4.6
通讯作者：
Chang AY
中科院分区：
文献类型：
--
作者：
Watson H;Nogueira-Hayd RL;Rodrigues-Moreno M;Naveca F;Calusi G;Suchowiecki K;Firestein GS;Simon G;Chang AY
慢性风湿病表现类似那些类风湿关节炎（RA）描述后基孔肯雅病毒感染。我们的目的是比较关节炎和慢性基孔肯雅病的关节计数和症状与临床结果的相关性。40名慢性基孔肯雅关节炎患者和40名RA患者参加了一项横断面研究。临床评估28个关节的压痛和肿胀的关系，并通过改进的健康评估问卷（HAQ）和生活质量（QoL）评估患者对疼痛和肌肉骨骼僵硬的评估。关节压痛和肿胀计数、疼痛和僵硬评分均与RA的HAQ残疾指数相关（r均为0.55,p≤0.0002），但基孔肯雅热中只有僵硬与残疾显著相关（r = 0.38, p = 0.02）。关节计数、疼痛和僵硬也与RA患者的大多数生活质量域相关。相比之下，在基孔肯雅病中，关节压痛计数仅与一个生活质量域相关，关节肿胀与一个生活质量域无关，而疼痛和僵硬与多个生活质量域相关。我们的研究结果证实了关节计数与RA的相关性，但表明在慢性基孔肯雅病中，关节计数的价值更有限。僵硬和疼痛评分可能更重要的量化基孔肯雅关节炎的影响。
Chronic rheumatological manifestations similar to those of rheumatoid arthritis (RA) are described after chikungunya virus infection. We aimed to compare the relevance of joint counts and symptoms to clinical outcomes in RA and chronic chikungunya disease. Forty patients with chronic chikungunya arthralgia and 40 patients with RA were enrolled in a cross-sectional study. The association of tenderness and swelling, clinically assessed in 28 joints, and patient evaluations of pain and musculoskeletal stiffness with modified Health Assessment Questionnaire (HAQ) and quality of life (QoL) assessments were investigated. Tender and swollen joint counts, pain and stiffness scores were all associated with the HAQ disability index in RA (all r > 0.55, p ≤ 0.0002), but only stiffness was significantly associated with disability in chikungunya (r = 0.38, p = 0.02). Joint counts, pain and stiffness were also associated with most QoL domains in RA patients. In contrast, in chikungunya disease, tender joint counts were associated only with one QoL domain and swollen joints for none, while pain and stiffness were associated with several domains. Our results confirm the relevance of joint counts in RA, but suggest that in chronic chikungunya disease, joint counts have more limited value. Stiffness and pain score may be more important to quantify chikungunya arthritis impact.
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DOI：
10.1093/infdis/jiq042
发表时间：
2011-01-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Chow A;Her Z;Ong EK;Chen JM;Dimatatac F;Kwek DJ;Barkham T;Yang H;Rénia L;Leo YS;Ng LF
通讯作者：
Ng LF
影响因子：
3.9
作者：
Sinnathurai, Premarani;Bartlett, Susan J.;March, Lyn
通讯作者：
March, Lyn
DOI：
10.1002/art.39027
发表时间：
2015-05
期刊：
Arthritis & rheumatology (Hoboken, N.J.)
影响因子：
--
作者：
Miner JJ;Aw-Yeang HX;Fox JM;Taffner S;Malkova ON;Oh ST;Kim AHJ;Diamond MS;Lenschow DJ;Yokoyama WM
通讯作者：
Yokoyama WM
影响因子：
3.5
作者：
Herdman, M.;Gudex, C.;Lloyd, A.;Janssen, M. F.;Kind, P.;Parkin, D.;Bonsel, G.;Badia, X.
通讯作者：
Badia, X.
影响因子：
27.4
作者：
Gossec, L.;Paternotte, S.;Kvien, T. K.
通讯作者：
Kvien, T. K.