Detection of human coronavirus NL63, human metapneumovirus and respiratory syncytial virus in children with respiratory tract infections in south-west Sweden.
Detection of human coronavirus NL63, human metapneumovirus and respiratory syncytial virus in children with respiratory tract infections in south-west Sweden.
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DOI：
10.1111/j.1469-0691.2006.01506.x
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发表时间：
2006-11
期刊：
影响因子：
--
通讯作者：
Ripa T
中科院分区：
文献类型：
--
作者：
Koetz A;Nilsson P;Lindén M;van der Hoek L;Ripa T
最近发现的两种病毒，人类偏肺病毒(HMPV)和冠状病毒NL63(HCoV-NL63)与急性呼吸道感染有关，特别是在幼儿中。本研究通过筛查2003年11月至2005年5月期间收集的221份鼻咽抽吸物，调查了瑞典儿童中hMPV和HCoV-NL63感染的频率，这些样本来自瑞典一家县医院儿科或当地全科医生提交的212名儿童。这些样本最初被提交进行呼吸道合胞病毒(RSV)检测，并通过RT-PCR对hMPV和HCoV-NL63进行了回顾性检查。212例患者中，RSV阳性101例(48%)，hMPV阳性22例(10%)，HCoV-NL63阳性12例(6%)。HCoV-NL63感染频率从2003-2004年的1%上升到2004-2005年的10%。部分冠状病毒基因组序列分析表明，与HCoV-NL63原型序列有相当大的相似性。研究表明，HCoV-NL63和hMPV在瑞典西南部发生的频率、季节分布和临床特征与其他国家报告的基本相同。
Two recently detected viruses, human metapneumovirus (hMPV) and coronavirus NL63 (HCoV‐NL63), have been associated with acute respiratory tract infections, particularly in young children. This study investigated the frequency of hMPV and HCoV‐NL63 infections in Swedish children by screening 221 nasopharyngeal aspirates, collected between November 2003 and May 2005, from 212 children attending the paediatric department of a county hospital in Sweden or submitted from local general practitioners. The samples were originally submitted to be tested for respiratory syncytial virus (RSV), and were examined retrospectively for hMPV and HCoV‐NL63 by RT‐PCR. Of the 212 patients, 101 were positive for RSV (48%), 22 (10%) were positive for hMPV, and 12 (6%) were positive for HCoV‐NL63. The frequency of HCoV‐NL63 infection increased from 1% in 2003–2004 to 10% in 2004–2005. Sequence analysis of parts of the coronavirus genomes showed considerable similarity to the HCoV‐NL63 prototype sequence. The study demonstrated that HCoV‐NL63 and hMPV occur in south‐west Sweden with essentially the same frequency, seasonal distribution and clinical characteristics as have been reported in other countries.
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DOI：
10.1016/s0140-6736(02)11391-2
发表时间：
2002-11-02
期刊：
Lancet (London, England)
影响因子：
--
作者：
Jartti T;van den Hoogen B;Garofalo RP;Osterhaus AD;Ruuskanen O
通讯作者：
Ruuskanen O
影响因子：
11.8
作者：
Mullins JA;Erdman DD;Weinberg GA;Edwards K;Hall CB;Walker FJ;Iwane M;Anderson LJ
通讯作者：
Anderson LJ
影响因子：
3.6
作者：
Suzuki, A;Okamoto, M;Nishimura, H
通讯作者：
Nishimura, H
影响因子：
9.4
作者：
Maertzdorf, J;Wang, CK;Fouchier, RAM
通讯作者：
Fouchier, RAM
影响因子：
11.8
作者：
Chiu, SS;Chan, KH;Peiris, JSM
通讯作者：
Peiris, JSM