Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner.
Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner.
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DOI：
10.1016/j.biopsych.2009.10.030
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发表时间：
2010-05-01
影响因子：
10.6
通讯作者：
Zigman, Jeffrey M.
中科院分区：
文献类型：
--
作者：
Perello, Mario;Sakata, Ichiro;Birnbaum, Shari;Chuang, Jen-Chieh;Osborne-Lawrence, Sherri;Rovinsky, Sherry A.;Woloszyn, Jakub;Yanagisawa, Masashi;Lutter, Michael;Zigman, Jeffrey M.
Ghrelin是一种有效的促食欲激素，可能通过几种机制影响饮食。在这里，我们假设Ghrelin可以调节饮食行为的超稳态和享乐主义方面。在目前的研究中，我们评估了不同的药物、生理和遗传模型对两种经典的奖赏行为测试：条件性位置偏爱(CPP)和操作条件反射(OPERATOR CONTRATION)的影响。使用CPP和操纵性条件作用，我们发现Ghrelin在给随机喂养的小鼠服用高脂饮食(HFD)时增加了奖励价值。相反，用Ghrelin受体拮抗剂治疗的野生型小鼠和Ghrelin受体缺失的小鼠都没有表现出对通常在热量限制下观察到的HFD的CPP。有趣的是，Ghrelin信号的药物或基因阻断都不能抑制与体重动态平衡相关的、与慢性热量限制相关的代偿性吞噬。此外，在食欲素缺乏的小鼠和用食欲素1受体拮抗剂治疗的野生型小鼠中，Ghrelin对HFD奖赏的影响被阻断。我们的结果表明，Ghrelin在饮食的某些有益方面发挥了强制性作用，这与与体重动态平衡相关的饮食是分开的，这需要完整的食欲素信号的存在。
Ghrelin is a potent orexigenic hormone that likely impacts eating via several mechanisms. Here, we hypothesized that ghrelin can regulate extra-homeostatic, hedonic aspects of eating behavior. In the current study, we assessed the effects of different pharmacological, physiological and genetic models of increased ghrelin and/or ghrelin signaling blockade on two classic behavioral tests of reward behavior: conditioned place preference (CPP) and operant conditioning. Using both CPP and operant conditioning, we found that ghrelin enhanced the rewarding value of high-fat diet (HFD) when administered to ad lib-fed mice. Conversely, wild-type mice treated with ghrelin receptor antagonist and ghrelin receptor-null mice both failed to show CPP to HFD normally observed under calorie restriction. Interestingly, neither pharmacologic nor genetic blockade of ghrelin signaling inhibited the body weight homeostasis-related, compensatory hyperphagia associated with chronic calorie restriction. Also, ghrelin's effects on HFD reward were blocked in orexin-deficient mice and wild-type mice treated with an orexin 1 receptor antagonist. Our results demonstrate an obligatory role for ghrelin in certain rewarding aspects of eating that is separate from eating associated with body weight homeostasis and that requires the presence of intact orexin signaling.
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影响因子：
2.5
作者：
FALLON, JH;MOORE, RY
通讯作者：
MOORE, RY
影响因子：
5.3
作者：
Lutter, Michael;Krishnan, Vaishnav;Nestler, Eric J.
通讯作者：
Nestler, Eric J.
影响因子：
15.9
作者：
Abizaid, Alfonso;Liu, Zhong-Wu;Horvath, Tamas L.
通讯作者：
Horvath, Tamas L.
影响因子：
29
作者：
Malik, Saima;McGlone, Francis;Dagher, Alain
通讯作者：
Dagher, Alain
DOI：
10.1016/s0169-328x(97)00071-5
发表时间：
1997-08-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Guan, XM;Yu, H;Howard, AD
通讯作者：
Howard, AD