Perivascular instruction of cell genesis and fate in the adult brain.
Perivascular instruction of cell genesis and fate in the adult brain.
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成人大脑中细胞起源和命运的血管周期教学。
DOI：
10.1038/nn.2963
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发表时间：
2011-10-26
影响因子：
25
通讯作者：
中科院分区：
文献类型：
--
作者：
神经发生的血管周围生态位首先被报道为新产生的神经元及其祖细胞与成年鸟类和哺乳动物大脑限制区域中分裂和有丝分裂静止的内皮细胞的共同关联。本文综述了血管与神经干细胞和神经祖细胞的相互作用，解决了神经胶质细胞和神经元祖细胞在血管周围生态位的相互作用。我们审查的分子相互作用，是最关键的内皮控制干细胞和祖细胞动员和分化。整个重点将是定义这些系统之间共享的血管周围配体-受体相互作用，以及那些明显不同的细胞类型和设置的功能，特异性可以在靶向治疗的发展中实现。
The perivascular niche for neurogenesis was first reported as the co-association of newly generated neurons and their progenitors with both dividing and mitotically quiescent endothelial cells in restricted regions of the brain in adult birds and mammals alike. This review attempts to summarize our present understanding of the interaction of blood vessels with neural stem and progenitor cells, addressing both glial and neuronal progenitor cell interactions in the perivascular niche. We review the molecular interactions that are most critical to the endothelial control of stem and progenitor cell mobilization and differentiation. The focus throughout will be on defining those perivascular ligand-receptor interactions shared among these systems, as well as those that clearly differ as a function of cell type and setting, by which specificity may be achieved in the development of targeted therapeutics.
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影响因子：
82.9
作者：
Eriksson, PS;Perfilieva, E;Gage, FH
通讯作者：
Gage, FH
影响因子：
5.2
作者：
Carreira, Bruno Pereira;Morte, Maria Ines;Araujo, Ines Maria
通讯作者：
Araujo, Ines Maria
影响因子：
5.3
作者：
Bovetti, Serena;Hsieh, Yi-Chun;Puche, Adam C.
通讯作者：
Puche, Adam C.
影响因子：
6.2
作者：
Agresti, C;Meomartini, ME;Visentin, S
通讯作者：
Visentin, S
影响因子：
5.3
作者：
Arai, Ken;Lo, Eng H.
通讯作者：
Lo, Eng H.