Fe3O4 nanoparticles with daunorubicin induce apoptosis through caspase 8-PARP pathway and inhibit K562 leukemia cell-induced tumor growth in vivo.
Fe3O4 nanoparticles with daunorubicin induce apoptosis through caspase 8-PARP pathway and inhibit K562 leukemia cell-induced tumor growth in vivo.
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DOI：
10.1016/j.nano.2011.01.013
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发表时间：
2011-10
影响因子：
5.4
通讯作者：
Chen, Yan-Hua
中科院分区：
文献类型：
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作者：
Zhang, Gen;Lai, Bin Bin;Zhou, Yan Yan;Chen, Bao An;Wang, Xue Mei;Lu, Qun;Chen, Yan-Hua
纳米材料可以增强抗癌药物的递送和治疗效率，但Fe 3 O 4纳米颗粒与柔红霉素的减瘤活性的机制尚未建立。在这里，我们调查的协同效应Fe 3 O 4纳米粒子与柔红霉素诱导K562白血病细胞凋亡。Fe 3 O 4纳米粒通过Caspase-8/Poly（ADP-ribose）聚合酶途径增强柔红霉素诱导阿霉素敏感和耐药K562细胞凋亡的能力。Fe 3 O 4纳米粒联合柔红霉素也能有效抑制K562细胞裸鼠移植瘤的生长。细胞凋亡率的增加与肿瘤生长抑制作用的增强密切相关。异种移植肿瘤的生物分布研究表明，Fe 3 O 4纳米颗粒可能通过胃肠道系统从体内排出。总之，我们的研究表明，Fe 3 O 4纳米颗粒与抗癌药物结合可以作为癌症治疗靶向治疗方法的更好选择。
Nanomaterials can enhance the delivery and treatment efficiency of anti-cancer drugs, but the mechanisms of the tumor-reducing activity of Fe3O4 nanoparticles with daunorubicin have not been established. Here we investigate the synergistic effects of Fe3O4 nanoparticles with daunorubicin on the induction of apoptosis using K562 leukemia cells. Fe3O4 nanoparticles increased the ability of daunorubicin to induce apoptosis in both adriamycin-sensitive and adriamycin-resistant K562 cells through Caspase-8/Poly (ADP-ribose) polymerase pathway. Fe3O4 nanoparticles combined with daunorubicin also effectively inhibited the tumor growth induced by the inoculation of K562 cells into nude mice. The increased cell apoptotic rate was closely correlated with the enhanced inhibition of tumor growth. Biodistribution studies in xenograft tumors indicated that Fe3O4 nanoparticles could be potentially excreted from the body via the gastrointestinal system. In conclusion, our study suggests that Fe3O4 nanoparticles combined with anti-cancer drugs could serve as a better alternative for the targeted therapeutic approaches to cancer treatments.
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影响因子：
2.7
作者：
Wu, Tony;Hua, Mu-Yi;Ma, Yunn-Hwa
通讯作者：
Ma, Yunn-Hwa
影响因子：
4.9
作者：
Ganta, Srinivas;Amiji, Mansoor
通讯作者：
Amiji, Mansoor
功能化镍纳米颗粒对白血病癌细胞的体外细胞摄取和细胞毒作用。
影响因子：
--
作者：
Guo, Dadong;Wu, Chunhui;Chen, Baoan
通讯作者：
Chen, Baoan
影响因子：
5.8
作者：
Gaur, U;Sahoo, SK;Ghosh, PK
通讯作者：
Ghosh, PK
影响因子：
9.3
作者：
Tofani, S;Barone, D;Eandi, A
通讯作者：
Eandi, A