Cross-sectional associations of CSF tau levels with Rey's AVLT: A recency ratio study.
Cross-sectional associations of CSF tau levels with Rey's AVLT: A recency ratio study.
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DOI：
10.1037/neu0000821
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发表时间：
2023-09
期刊：
影响因子：
2.4
通讯作者：
Mueller, Kimberly D.
中科院分区：
文献类型：
--
作者：
Bruno, Davide;Zinkunegi, Ainara Jauregi;Pomara, Nunzio;Zetterberg, Henrik;Blennow, Kaj;Koscik, Rebecca Langhough;Carlsson, Cynthia;Bendlin, Barbara;Okonkwo, Ozioma;Hermann, Bruce P.;Johnson, Sterling C.;Mueller, Kimberly D.
阿尔茨海默病（AD）最重要的体内脑脊液（CSF）生物标志物是β淀粉样蛋白1 - 42（Aβ42）、磷酸化tau蛋白（p - tau）和总tau蛋白（t - tau）。本研究的目的是检验从雷伊听觉词语学习测验（AVLT）得出的传统（总分和延迟回忆）和基于过程（近因比率[Rr]）的测量指标与这些生物标志物的关联程度。
从威斯康星阿尔茨海默病预防登记处提取了235名参与者的数据（平均年龄 = 65.5岁，标准差 = 6.9），这些参与者从认知未受损到轻度认知障碍不等，且有脑脊液数值。以脑脊液分数为结果，AVLT分数为预测因子，并控制人口统计学数据和诊断进行贝叶斯回归分析。
我们发现有适度证据表明，在控制变量之外，Rr与脑脊液p - tau（贝叶斯因子[BFM] = 5.55）和t - tau（BFM = 7.28）均相关，而与脑脊液Aβ42水平无关。相比之下，在单独分析中，总分和延迟回忆分数与任何AD生物标志物均无关联。当在单一回归中比较所有记忆预测因子时，Rr仍然是脑脊液t - tau水平的最强预测因子（BFM = 3.57）。
我们的研究结果表明，在评估非痴呆个体的脑脊液p - tau和t - tau水平方面，Rr可能是比常用的AVLT分数更好的认知测量指标。
The preeminent in vivo cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease (AD) are amyloid β 1–42 (Aβ42), phosphorylated Tau (p-tau), and total Tau (t-tau). The goal of this study was to examine how well traditional (total and delayed recall) and process-based (recency ratio [Rr]) measures derived from Rey’s Auditory Verbal Learning test (AVLT) were associated with these biomarkers. Data from 235 participants (Mage = 65.5, SD = 6.9), who ranged from cognitively unimpaired to mild cognitive impairment, and for whom CSF values were available, were extracted from the Wisconsin Registry for Alzheimer’s Prevention. Bayesian regression analyses were carried out using CSF scores as outcomes, AVLT scores as predictors, and controlling for demographic data and diagnosis. We found moderate evidence that Rr was associated with both CSF p-tau (Bayesian factor [BFM] = 5.55) and t-tau (BFM = 7.28), above and beyond the control variables, while it did not correlate with CSF Aβ42 levels. In contrast, total and delayed recall scores were not linked with any of the AD biomarkers, in separate analyses. When comparing all memory predictors in a single regression, Rr remained the strongest predictor of CSF t-tau levels (BFM = 3.57). Our findings suggest that Rr may be a better cognitive measure than commonly used AVLT scores to assess CSF levels of p-tau and t-tau in nondemented individuals.
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影响因子：
2.2
作者：
Bruno D;Mueller KD;Betthauser T;Chin N;Engelman CD;Christian B;Koscik RL;Johnson SC
通讯作者：
Johnson SC
DOI：
10.1016/j.jalz.2011.03.005
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
McKhann GM;Knopman DS;Chertkow H;Hyman BT;Jack CR Jr;Kawas CH;Klunk WE;Koroshetz WJ;Manly JJ;Mayeux R;Mohs RC;Morris JC;Rossor MN;Scheltens P;Carrillo MC;Thies B;Weintraub S;Phelps CH
通讯作者：
Phelps CH
影响因子：
2.4
作者：
Koscik RL;La Rue A;Jonaitis EM;Okonkwo OC;Johnson SC;Bendlin BB;Hermann BP;Sager MA
通讯作者：
Sager MA
影响因子：
4
作者：
Bruno, Davide;Gleason, Carey E.;Johnson, Sterling C.
通讯作者：
Johnson, Sterling C.
DOI：
10.1017/s1355617702813157
发表时间：
2002-03-01
影响因子：
2.6
作者：
Manly, JJ;Jacobs, DM;Stern, Y
通讯作者：
Stern, Y