Elevated C-reactive protein is related to cognitive decline in older adults with cardiovascular disease.
Elevated C-reactive protein is related to cognitive decline in older adults with cardiovascular disease.
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DOI：
10.1111/j.1532-5415.2008.01930.x
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发表时间：
2008-10
影响因子：
6.3
通讯作者：
Cohen RA
中科院分区：
文献类型：
--
作者：
Hoth KF;Haley AP;Gunstad J;Paul RH;Poppas A;Jefferson AL;Tate DF;Ono M;Jerskey BA;Cohen RA
在1年的随访期间，前瞻性地将c反应蛋白（CRP）（一种全身炎症标志物）与认知变化联系起来。前瞻性1年随访。门诊大学医疗设置。78名成人（56-84岁，39%为女性）患有心血管疾病。CRP水平采用高灵敏度测定法测量，参与者在研究开始时完成神经心理学测试。1年后再次进行神经心理评估。在1年的随访中，使用层次线性回归模型对五个认知领域（全球认知、语言、记忆、视觉空间能力和注意-执行-精神运动）检测CRP与认知变化之间的关系。在调整研究开始时年龄和认知表现的影响后，高CRP水平与注意力-执行-精神运动表现的轻微下降相关（CRP β = - 0.22, P = 0.04）。CRP与语言、记忆或视觉空间表现的变化无显著相关性。这些数据提供了初步证据，表明炎症可能导致动脉粥样硬化过程，可能是高CRP与注意力-执行-精神运动表现变化之间联系的基础。
To prospectively relate C-reactive protein (CRP), a systemic marker of inflammation, to cognitive change over a 1-year follow-up period. Prospective 1-year follow-up. Outpatient university medical setting. Seventy-eight adults (aged 56–84; 39% female) with cardiovascular disease. CRP levels were measured using a high-sensitivity assay, and participants completed a neuropsychological battery at study entry. Neuropsychological assessment was repeated 1 year later. The association between CRP and change in cognition over the 1-year follow-up was examined using hierarchical linear regression modeling for five cognitive domains (global cognition, language, memory, visuospatial abilities, and attention-executive-psychomotor). High CRP levels were associated with subtle declines in attention-executive-psychomotor performance (CRP β = −0.22, P = .04) after adjusting for the effects of age and cognitive performance at study entry. CRP was not significantly associated with change in language, memory, or visuospatial performance. These data provide preliminary evidence that inflammation, potentially contributing to atherosclerotic processes, may underlie the association between high CRP and changes in attention-executive-psychomotor performance.
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影响因子：
37.8
作者：
Pearson, TA;Mensah, GA;Vinicor, F
通讯作者：
Vinicor, F
影响因子：
2.6
作者：
Jefferson, Angela L.;Paul, Robert H.;Cohen, Ronald A.
通讯作者：
Cohen, Ronald A.
影响因子：
8.3
作者：
Laukka, EJ;Jones, S;Bäckman, L
通讯作者：
Bäckman, L
影响因子：
9.9
作者：
Dik, MG;Jonker, C;Eikelenboom, P
通讯作者：
Eikelenboom, P
影响因子：
4.8
作者：
FOLSTEIN, MF;FOLSTEIN, SE;MCHUGH, PR
通讯作者：
MCHUGH, PR