Volumetric effects of motor cortex injury on recovery of dexterous movements.
Volumetric effects of motor cortex injury on recovery of dexterous movements.
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DOI：
10.1016/j.expneurol.2009.07.034
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发表时间：
2009-11
影响因子：
5.3
通讯作者：
Morecraft, Robert J.
中科院分区：
文献类型：
--
作者：
Darling, Warren G.;Pizzimenti, Marc A.;Rotella, Diane L.;Peterson, Clayton R.;Hynes, Stephanie M.;Ge, Jizhi;Solon, Kathryn;McNeal, David W.;Stilwell-Morecraft, Kimberly S.;Morecraft, Robert J.
由于大多数脑损伤的异质性，灰质和白质参与对运动缺陷和恢复潜力的贡献仍然不清楚。我们测试了这样的假设：手部运动损伤的持续时间以及熟练的手臂和手部运动功能的恢复取决于额叶灰质和白质损伤的体积。在恒河猴中评估了初级运动皮层（M1）、M1 + 外侧前运动皮层（LPMC）、M1 + LPMC + 辅助运动皮层（M2）的病变或多灶性病变影响运动区和内侧前额叶皮层。使用两次运动测试对病变前和病变后 3-12 个月的手部精细运动功能进行定量评估。使用组织学和定量方法测定白质和灰质病变体积。回归分析显示，手部精细运动损伤的持续时间与灰质和白质病变的体积密切相关（R2 > 0.8），其中白质病变体积是损伤持续时间的主要预测因素。手部精细运动技能的恢复水平也与灰质和白质病变体积密切相关（R2 > 0.5）。在一些猴子中，在一项或两项运动任务中，损伤后的技能超过了损伤前的技能，这表明持续的损伤后任务练习可以在额叶运动皮层局部丧失后提高运动表现。这些发现将有助于解释急性运动缺陷，预测功能恢复的时间过程和预期水平，并为局部额叶损伤或神经外科切除患者设计治疗策略。
Due to the heterogeneous nature of most brain injuries, the contributions of gray and white matter involvement to motor deficits and recovery potential remain obscure. We tested the hypothesis that duration of hand motor impairment and recovery of skilled arm and hand motor function depends on the volume of gray and white matter damage of the frontal lobe. Lesions of the primary motor cortex (M1), M1 + lateral premotor cortex (LPMC), M1 + LPMC + supplementary motor cortex (M2) or multi-focal lesions affecting motor areas and medial prefrontal cortex were evaluated in rhesus monkeys. Fine hand motor function was quantitatively assessed pre-lesion and for 3–12 months post-lesion using two motor tests. White and gray matter lesion volumes were determined using histological and quantitative methods. Regression analyses showed that duration of fine hand motor impairment was strongly correlated (R2 > 0.8) with the volume of gray and white matter lesions, with white matter lesion volume being the primary predictor of impairment duration. Level of recovery of fine hand motor skill was also well correlated (R2 > 0.5) with gray and white matter lesion volume. In some monkeys post-lesion skill exceeded pre-lesion skill in one or both motor tasks demonstrating that continued post-injury task practice can improve motor performance after localized loss of frontal motor cortex. These findings will assist in interpreting acute motor deficits, predicting the time course and expected level of functional recovery, and designing therapeutic strategies in patients with localized frontal lobe injury or neurosurgical resection.
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影响因子：
5.7
作者：
Jelsing, J;Rostrup, E;Pakkenberg, B
通讯作者：
Pakkenberg, B
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作者：
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通讯作者：
BUCY, P C
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作者：
Darling, WG;Peterson, CR;Morecraft, RJ
通讯作者：
Morecraft, RJ