Lateral Corticospinal Tract and Dorsal Column Damage: Predictive Relationships With Motor and Sensory Scores at Discharge From Acute Rehabilitation After Spinal Cord Injury.
Lateral Corticospinal Tract and Dorsal Column Damage: Predictive Relationships With Motor and Sensory Scores at Discharge From Acute Rehabilitation After Spinal Cord Injury.
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DOI：
10.1016/j.apmr.2021.07.792
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发表时间：
2022-01
影响因子：
4.3
通讯作者：
Weber KA
中科院分区：
文献类型：
--
作者：
Smith AC;O'Dell DR;Albin SR;Berliner JC;Dungan D;Robinson E;Elliott JM;Carballido-Gamio J;Stevens-Lapsley J;Weber KA
确定脊髓皮质侧束（LCST）的完整性是否与未来同侧下肢运动功能（LEMS）有显著的预测关系，以及脊髓背柱（DC）的完整性是否与SCI后出院时的未来轻触（LT）感觉功能有显著的预测关系。影像学和临床结局的回顾性分析。大学和学术医院。151名SCI患者。住院康复。住院康复出院时的LEMS和LT评分。在151名参与者中，右侧LCST备用组织与右侧LEMS恢复百分比具有显著的预测关系（β = 0.56，95% CI：0.37，0.73，R = 0.43，p < 0.001）。左侧LCST备用组织显示与左侧LEMS恢复百分比的显著预测关系（β = 0.66，95%CI：0.50，0.82，R = 0.51，p < 0.001）。DC备用组织表现出与恢复的LT百分比的显著预测关系（β = 0.69，95%CI：0.52，0.87，R = 0.55，p < 0.001）。当将参与者分为运动完全和不完全SCI时，运动关系不再重要，但感觉关系仍然重要。那些没有随意运动功能但恢复了一些的人与那些没有恢复运动功能的人相比，也有显着更大的LCST备用组织。LCST表现出显着的中度预测关系与下肢运动功能出院时，从住院康复，在同病的方式。DC的完整性表现出显着的中度预测关系与LT的功能恢复。随着进一步的发展，这些神经影像学方法可能被用来预测潜在的缺陷后SCI，并提供相应的有针对性的干预措施。
to determine if lateral corticospinal tract (LCST) integrity demonstrates a significant predictive relationship with future ipsilateral lower extremity motor function (LEMS), and if dorsal column (DC) integrity demonstrates a significant predictive relationship with future light touch (LT) sensory function post SCI at time of discharge from inpatient rehabilitation. retrospective analyses of imaging and clinical outcomes. University and academic hospital. 151 participants with SCI. Inpatient rehabilitation. LEMS and LT scores at discharge from inpatient rehabilitation. In 151 participants, right LCST spared tissue demonstrated a significant predictive relationship with right LEMS percent recovered (β = 0.56, 95% CI: 0.37, 0.73, R = 0.43, p < 0.001). Left LCST spared tissue demonstrated a significant predictive relationship with left LEMS percent recovered (β = 0.66, 95% CI: 0.50, 0.82, R = 0.51, p < 0.001). DC spared tissue demonstrated a significant predictive relationship with LT percent recovered (β = 0.69, 95% CI: 0.52, 0.87, R = 0.55, p < 0.001). When subgrouping the participants into motor complete versus incomplete SCI, motor relationships were no longer significant but the sensory relationship remained significant. Those who had no voluntary motor function but recovered some also had significantly greater LCST spared tissue compared to those who did not recover motor function. LCST demonstrated significant moderate predictive relationships with lower extremity motor function at the time of discharge from inpatient rehabilitation, in an ipsilesional manner. DC integrity demonstrated a significant moderate predictive relationship with recovered function of LT. With further development, these neuroimaging methods might be used to predict potential deficits following SCI and to provide corresponding targeted interventions.
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DOI：
10.1136/jnnp-2020-323150
发表时间：
2020-10
期刊：
Journal of neurology, neurosurgery, and psychiatry
影响因子：
--
作者：
Pfyffer D;Vallotton K;Curt A;Freund P
通讯作者：
Freund P
影响因子：
1.7
作者：
O'Dell, Denise R.;Weber, Kenneth A.;Smith, Andrew C.
通讯作者：
Smith, Andrew C.
影响因子：
1.7
作者：
Berliner, Jeffrey C.;O'Dell, Denise R.;Smith, Andrew C.
通讯作者：
Smith, Andrew C.
影响因子：
5.7
作者：
De Leener, Benjamin;Fonov, Vladimir S.;Cohen-Adad, Julien
通讯作者：
Cohen-Adad, Julien
影响因子：
1.2
作者：
Cummins, David P.;Connor, Jordan R.;Smith, Andrew C.
通讯作者：
Smith, Andrew C.