The Potential Role of Hepatocyte Growth Factor in Degenerative Disorders of the Synovial Joint and Spine.
The Potential Role of Hepatocyte Growth Factor in Degenerative Disorders of the Synovial Joint and Spine.
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DOI：
10.3390/ijms21228717
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发表时间：
2020-11-18
影响因子：
5.6
通讯作者：
Takahashi K
中科院分区：
文献类型：
--
作者：
Tonomura H;Nagae M;Takatori R;Ishibashi H;Itsuji T;Takahashi K
本文的目的是提供一个全面的审查肝细胞生长因子（HGF）信号在健康和患病的滑膜关节和脊柱的变化作用。HGF是一种多功能生长因子，与其特异性受体c-Met一样，在多种骨和关节组织中广泛表达。HGF对细胞存活和增殖、基质代谢、炎症反应和神经营养作用具有深远的影响。HGF在正常骨和软骨转换中起重要作用。HGF/c-Met的变化也与退行性关节疾病（如骨关节炎（OA）和椎间盘退变（IDD））的病理生理学变化有关。已经提出了HGF在骨关节组织再生中的治疗作用。HGF还影响骨重建和周围神经活动。因此，需要进一步研究HGF/c-Met信号通路在OA和IDD不同病理生理阶段的变化及其分子机制。这些研究将有助于安全和有效的HGF/c-Met信号为基础的治疗OA和IDD。
This paper aims to provide a comprehensive review of the changing role of hepatocyte growth factor (HGF) signaling in the healthy and diseased synovial joint and spine. HGF is a multifunctional growth factor that, like its specific receptor c-Met, is widely expressed in several bone and joint tissues. HGF has profound effects on cell survival and proliferation, matrix metabolism, inflammatory response, and neurotrophic action. HGF plays an important role in normal bone and cartilage turnover. Changes in HGF/c-Met have also been linked to pathophysiological changes in degenerative joint diseases, such as osteoarthritis (OA) and intervertebral disc degeneration (IDD). A therapeutic role of HGF has been proposed in the regeneration of osteoarticular tissues. HGF also influences bone remodeling and peripheral nerve activity. Studies aimed at elucidating the changing role of HGF/c-Met signaling in OA and IDD at different pathophysiological stages, and their specific molecular mechanisms are needed. Such studies will contribute to safe and effective HGF/c-Met signaling-based treatments for OA and IDD.
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影响因子：
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作者：
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DOI：
10.1002/jbmr.4009
发表时间：
2020-08
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
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作者：
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