Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness.
Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness.
复制标题
DOI：
10.1371/journal.pone.0188122
复制
发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Raichle M
中科院分区：
文献类型：
--
作者：
Mitra A;Snyder AZ;Tagliazucchi E;Laufs H;Elison J;Emerson RW;Shen MD;Wolff JJ;Botteron KN;Dager S;Estes AM;Evans A;Gerig G;Hazlett HC;Paterson SJ;Schultz RT;Styner MA;Zwaigenbaum L;IBIS Network;Schlaggar BL;Piven J;Pruett JR Jr;Raichle M
婴儿静息态功能磁共振成像 (rs-fMRI) 能够对人类发育早期的功能性大脑组织进行重要研究。然而，婴儿的rs-fMRI普遍是在睡眠期间获得的，以减少参与者的运动伪影，这就提出了一个问题：清醒的成年人和睡眠的婴儿之间通常归因于发育的功能组织差异是否可能至少部分源自睡眠。这个问题尤其重要，因为成人清醒状态与睡眠状态下的 rs-fMRI 差异已得到充分记录。为了研究这个问题，我们将 6、12 和 24 个月大的睡眠婴儿的功能连接和 BOLD 信号传播模式与成人清醒和非快速眼动睡眠的模式进行了比较。我们发现婴儿睡眠期间看到的重要功能连接特征与成人睡眠期间看到的非常相似，包括默认模式网络功能连接的减少。然而，我们也发现婴儿和成人睡眠之间的差异，特别是丘脑 BOLD 信号传播模式。这些发现强调了在婴儿 rs-fMRI 中进行发育推断时考虑睡眠状态的重要性。
Resting state functional magnetic resonance imaging (rs-fMRI) in infants enables important studies of functional brain organization early in human development. However, rs-fMRI in infants has universally been obtained during sleep to reduce participant motion artifact, raising the question of whether differences in functional organization between awake adults and sleeping infants that are commonly attributed to development may instead derive, at least in part, from sleep. This question is especially important as rs-fMRI differences in adult wake vs. sleep are well documented. To investigate this question, we compared functional connectivity and BOLD signal propagation patterns in 6, 12, and 24 month old sleeping infants with patterns in adult wakefulness and non-REM sleep. We find that important functional connectivity features seen during infant sleep closely resemble those seen during adult sleep, including reduced default mode network functional connectivity. However, we also find differences between infant and adult sleep, especially in thalamic BOLD signal propagation patterns. These findings highlight the importance of considering sleep state when drawing developmental inferences in infant rs-fMRI.
登录
查看更多内容
DOI：
10.3174/ajnr.a1256
发表时间：
2008-11
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Lin W;Zhu Q;Gao W;Chen Y;Toh CH;Styner M;Gerig G;Smith JK;Biswal B;Gilmore JH
通讯作者：
Gilmore JH
DOI：
10.1073/pnas.0900924106
发表时间：
2009-03-17
影响因子：
11.1
作者：
Larson-Prior, Linda J.;Zempel, John M.;Raichle, Marcus E.
通讯作者：
Raichle, Marcus E.
影响因子：
56.9
作者：
CHUGANI, HT;PHELPS, ME
通讯作者：
PHELPS, ME
影响因子：
3.7
作者：
Friedrichs-Maeder, Cecilia L.;Griffa, Alessandra;Hagmann, Patric
通讯作者：
Hagmann, Patric
影响因子：
3.9
作者：
Lord, C;Risi, S;Rutter, M
通讯作者：
Rutter, M