Thalamocortical dysconnectivity in schizophrenia.
Thalamocortical dysconnectivity in schizophrenia.
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DOI：
10.1176/appi.ajp.2012.12010056
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发表时间：
2012-10
期刊：
影响因子：
--
通讯作者：
Heckers S
中科院分区：
文献类型：
--
作者：
Woodward ND;Karbasforoushan H;Heckers S
丘脑和大脑皮层通过有组织的地形相互连接。先前的研究揭示了精神分裂症患者的丘脑异常；然而，尚不清楚丘脑皮质网络是否在这种疾病中受到不同的影响。为了探索这种可能性，我们使用静息状态功能磁共振成像检查了皮层和丘脑主要分区之间固有低频血氧水平依赖（BOLD）信号波动的功能连通性。对77名健康受试者和62名精神分裂症患者进行静息状态fMRI检查。为了确定丘脑的功能细分，我们将皮质分成六个感兴趣的区域；前额叶，运动，体感，颞叶，后顶叶和枕叶皮层。从每个感兴趣的区域提取平均BOLD时间序列，并进入基于种子的功能连通性分析。与先前的报道一致，在健康受试者和精神分裂症患者中，不同皮质区域的活动与丘脑的特定区域相关，这些区域在很大程度上不重叠。组间直接比较显示，精神分裂症患者前额叶-丘脑连通性降低，运动/体感-丘脑连通性增加。连通性的变化与丘脑局部灰质含量和抗精神病药物剂量无关。在颞叶、后顶叶和枕叶皮层与丘脑的连通性方面没有观察到差异。本研究确立了精神分裂症患者丘脑皮质网络的差异异常。精神分裂症的病因学可能会破坏大脑成熟过程中前额叶-丘脑连通性的发展以及与丘脑的躯体运动连通性的完善。
The thalamus and cerebral cortex are connected via topographically organized, reciprocal connections. Previous studies revealed thalamic abnormalities in schizophrenia; however, it is not known if thalamocortical networks are differentially affected in the disorder. To explore this possibility, we examined functional connectivity in intrinsic low frequency blood-oxygen-level-dependent (BOLD) signal fluctuations between major divisions of the cortex and thalamus using resting-state functional magnetic resonance imaging. 77 healthy subjects and 62 patients with schizophrenia underwent resting-state fMRI. To identify functional subdivisions of the thalamus, we parceled the cortex into six regions-of-interest; prefrontal, motor, somatosensory, temporal, posterior parietal, and occipital cortex. Mean BOLD time-series was extracted from each of the regions-of-interest and entered into a seed-based functional connectivity analysis. Consistent with prior reports, activity in distinct cortical areas correlated with specific, largely non-overlapping regions of the thalamus in both healthy subjects and schizophrenia patients. Direct comparison between groups revealed reduced prefrontal-thalamic connectivity and increased motor/somatosensory-thalamic connectivity in schizophrenia. The changes in connectivity were unrelated to local grey matter content within the thalamus and antipsychotic medication dosage. No differences were observed in temporal, posterior parietal, and occipital cortex connectivity with the thalamus. This study establishes differential abnormalities of thalamocortical networks in schizophrenia. The etiology of schizophrenia may disrupt the development of prefrontal-thalamic connectivity and refinement of somatomotor connectivity with the thalamus that occurs during brain maturation.
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影响因子：
5.7
作者：
Shattuck, David W.;Mirza, Mubeena;Toga, Arthur W.
通讯作者：
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影响因子：
3.7
作者：
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通讯作者：
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DOI：
10.1073/pnas.0900924106
发表时间：
2009-03-17
影响因子：
11.1
作者：
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通讯作者：
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作者：
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通讯作者：
Glahn, David C.
DOI：
10.1073/pnas.0905314106
发表时间：
2009-11-24
影响因子：
11.1
作者：
Margulies, Daniel S.;Vincent, Justin L.;Petrides, Michael
通讯作者：
Petrides, Michael