T cell accumulation in B cell follicles is regulated by dendritic cells and is independent of B cell activation.
T cell accumulation in B cell follicles is regulated by dendritic cells and is independent of B cell activation.
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DOI：
10.1084/jem.20021750
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发表时间：
2003-01-20
期刊：
影响因子：
--
通讯作者：
Gray D
中科院分区：
文献类型：
--
作者：
Fillatreau S;Gray D
We investigated the mechanism of CD4 T cell accumulation in B cell follicles after immunization. Follicular T cell numbers were correlated with the number of B cells, indicating B cell control of the niche that T cells occupy. Despite this, we found no role for B cells in the follicular migration of T cells. Instead, T cells are induced to migrate into B cell follicles entirely as a result of interaction with dendritic cells (DCs). Migration relies on CD40-dependent maturation of DCs, as it did not occur in CD40-deficient mice but was reconstituted with CD40+ DCs. Restoration was not achieved by the activation of DCs with bacterial activators (e.g., lipopolysaccharide, CpG), but was by the injection of OX40L–huIgG1 fusion protein. Crucially, the up-regulation of OX40L (on antigen-presenting cells) and CXCR-5 (on T cells) are CD40-dependent events and we show that T cells do not migrate to follicles in immunized OX40-deficient mice.
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