The SaeRS Two-Component System of Staphylococcus aureus.
The SaeRS Two-Component System of Staphylococcus aureus.
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金黄色葡萄球菌的 SaeRS 双组分系统
作者：
Liu Q;Yeo WS;Bae T
在革兰氏阳性致病菌金黄色葡萄球菌中，SaeRS 双组分系统 (TCS) 在控制 20 多种毒力因子（包括溶血素、杀白细胞素、超抗原、表面蛋白和蛋白酶）的产生方面发挥着重要作用。 SaeRS TCS 由传感器组氨酸激酶 SaeS、反应调节器 SaeR 和两个辅助蛋白 SaeP 和 SaeQ 组成。自 1994 年发现以来，sae 基因座已被广泛研究，其对葡萄球菌毒力和发病机制的贡献已得到充分记录和了解；然而，SaeRS TCS 接收和处理同源信号的分子机制却并非如此。因此，在本文中，我们回顾了关注信号机制及其与其他全球监管机构相互作用的文献。
In the Gram-positive pathogenic bacterium Staphylococcus aureus, the SaeRS two-component system (TCS) plays a major role in controlling the production of over 20 virulence factors including hemolysins, leukocidins, superantigens, surface proteins, and proteases. The SaeRS TCS is composed of the sensor histidine kinase SaeS, response regulator SaeR, and two auxiliary proteins SaeP and SaeQ. Since its discovery in 1994, the sae locus has been studied extensively, and its contributions to staphylococcal virulence and pathogenesis have been well documented and understood; however, the molecular mechanism by which the SaeRS TCS receives and processes cognate signals is not. In this article, therefore, we review the literature focusing on the signaling mechanism and its interaction with other global regulators.
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影响因子：
3.6
作者：
Beenken KE;Mrak LN;Zielinska AK;Atwood DN;Loughran AJ;Griffin LM;Matthews KA;Anthony AM;Spencer HJ;Skinner RA;Post GR;Lee CY;Smeltzer MS
通讯作者：
Smeltzer MS
影响因子：
4.4
作者：
Baker, Jonathan;Sitthisak, Sutthirat;Morrissey, Julie A.
通讯作者：
Morrissey, Julie A.
影响因子：
3.1
作者：
Beenken, KE;Blevins, JS;Smeltzer, MS
通讯作者：
Smeltzer, MS
影响因子：
6.7
作者：
Cho H;Jeong DW;Liu Q;Yeo WS;Vogl T;Skaar EP;Chazin WJ;Bae T
通讯作者：
Bae T
影响因子：
11.3
作者：
Cheung GY;Joo HS;Chatterjee SS;Otto M
通讯作者：
Otto M