Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review.

Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review.
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胃食管反流病流行病学最新进展:系统评价。

DOI:
10.1136/gutjnl-2012-304269
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发表时间:
2014-06
期刊:
Gut
影响因子:
24.5
通讯作者:
Dent J
Dent J
中科院分区:
医学1区
文献类型:
--
作者:
El-Serag HB;Sweet S;Winchester CC;Dent J

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更新2005年评估胃食管反流病(GERD)流行病学的基于人群研究的系统性综述的结果。使用原始检索字符串筛选PubMed和Embase中的新参考文献。研究必须以人群为基础,包括≥200名个体,应答率≥50%,回忆期<12个月。GERD定义为每周至少1天出现胃灼热和/或反流,或根据蒙特利尔定义,或由临床医生诊断。疾病流行的时间和地理趋势进行了检查,使用泊松回归模型。发现自最初审查以来发表的16项GERD流行病学研究适合纳入(15项报告患病率和1项报告发病率),并将其添加到先前发现的13项患病率和2项发病率研究中。北美、欧洲、东亚、中东、澳大利亚和南美的GERD患病率估计范围分别为18.1%-27.8%、8.8%-25.9%、2.5%-7.8%、8.7%-33.1%、11.6%和23.0%。英国和美国总体人群的发病率约为每1000人年5例,英国1- 17岁儿科患者的发病率为0.84例。有证据表明自1995年以来GERD患病率增加(p<0.0001),特别是在北美和东亚。GERD在全球范围内普遍存在,疾病负担可能会增加。流行率估计显示了相当大的地理差异,但只有东亚显示估计值始终低于10%。
To update the findings of the 2005 systematic review of population-based studies assessing the epidemiology of gastro-oesophageal reflux disease (GERD). PubMed and Embase were screened for new references using the original search strings. Studies were required to be population-based, to include ≥200 individuals, to have response rates ≥50% and recall periods <12 months. GERD was defined as heartburn and/or regurgitation on at least 1 day a week, or according to the Montreal definition, or diagnosed by a clinician. Temporal and geographic trends in disease prevalence were examined using a Poisson regression model. 16 studies of GERD epidemiology published since the original review were found to be suitable for inclusion (15 reporting prevalence and one reporting incidence), and were added to the 13 prevalence and two incidence studies found previously. The range of GERD prevalence estimates was 18.1%–27.8% in North America, 8.8%–25.9% in Europe, 2.5%–7.8% in East Asia, 8.7%–33.1% in the Middle East, 11.6% in Australia and 23.0% in South America. Incidence per 1000 person-years was approximately 5 in the overall UK and US populations, and 0.84 in paediatric patients aged 1– 17 years in the UK. Evidence suggests an increase in GERD prevalence since 1995 (p<0.0001), particularly in North America and East Asia. GERD is prevalent worldwide, and disease burden may be increasing. Prevalence estimates show considerable geographic variation, but only East Asia shows estimates consistently lower than 10%.
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发表时间: 2009-07-21
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影响因子: --
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