Feasibility of a Novel Sparse Orthogonal Collimator-Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality.
Feasibility of a Novel Sparse Orthogonal Collimator-Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality.
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DOI：
10.3389/fonc.2022.941814
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发表时间：
2022
影响因子：
4.7
通讯作者：
Hui, Susanta K.
中科院分区：
文献类型：
--
作者：
Abdelhamid, Amr M. H.;Jiang, Lu;Zuro, Darren;Liu, An;Madabushi, Srideshikan Sargur;Ghimire, Hemendra;Wong, Jeffrey Y. C.;Saldi, Simonetta;Fulcheri, Christian;Zucchetti, Claudio;Pierini, Antonio;Sheng, Ke;Aristei, Cynthia;Hui, Susanta K.
总骨髓辐射（TMI）通过降低调节性毒性并改善接力/冷藏性患者的生存结果，可以改善血液学疾病的造血细胞移植的辐射条件临床前的RIC比较临床TMI表明，临床前TMI治疗缺乏将剂量减少到非常接近骨骼系统的一些重要器官，因此限制了评估放射性生物学相关性的能力。显着改善TMI治疗通过减少接近骨骼系统的关键器官的辐射暴露来减少临床和临床前TMI之间的间隙。
Total marrow irradiation (TMI) has significantly improved radiation conditioning for hematopoietic cell transplantation in hematologic diseases by reducing conditioning-induced toxicities and improving survival outcomes in relapsed/refractory patients. Recently, preclinical three-dimensional image–guided TMI has been developed to enhance mechanistic understanding of the role of TMI and to support the development of experimental therapeutics. However, a dosimetric comparison between preclinical and clinical TMI reveals that the preclinical TMI treatment lacks the ability to reduce the dose to some of the vital organs that are very close to the skeletal system and thus limits the ability to evaluate radiobiological relevance. To overcome this limit, we introduce a novel Sparse Orthogonal Collimator (SOC)–based TMI and evaluate its ability to enhance dosimetric conformality. The SOC-TMI–based dose modulation technique significantly improves TMI treatment planning by reducing radiation exposures to critical organs that are close to the skeletal system that leads to reducing the gap between clinical and preclinical TMI.
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