The microsomal triglyceride transfer protein inhibitor lomitapide improves vascular function in mice with obesity.
The microsomal triglyceride transfer protein inhibitor lomitapide improves vascular function in mice with obesity.
复制标题
微粒体甘油三酯转移蛋白抑制剂洛美他派可改善肥胖小鼠的血管功能。
DOI：
10.1002/oby.23389
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发表时间：
2022-04
期刊：
影响因子：
--
通讯作者：
Kassan M
中科院分区：
文献类型：
--
作者：
Munkhsaikhan U;Kwon Y;Sahyoun AM;Ait-Aissa K;Kassan A;Kassan M
在这项研究中，我们探讨洛美他派，一种微粒体甘油三酯转移蛋白抑制剂，对肥胖心血管功能的影响。在存在和不存在洛美他派的情况下，用高脂肪饮食（HFD）喂养八周龄C57 BL/6小鼠12周。在HFD喂养的最后2周期间，通过灌胃给予洛美他派（1 mg/Kg/天）。测定体重、血糖、身体成分和血脂。检测主动脉和肠系膜阻力动脉（MRA）的血管功能和内皮功能指标。洛美他派治疗降低了肥胖小鼠的体重。洛美他派治疗后，血糖、脂肪量%、总胆固醇和LDL水平显著降低，瘦体重%显著增加。主动脉和肠系膜动脉血管对硝普钠（SNP）的反应在各组之间相似。但治疗组血管对乙酰胆碱（Ach）的反应性有所改善。这与血管内质网（ER）应激、炎症和氧化应激水平降低有关。洛美他派治疗减轻了肥胖小鼠的体重增加，并恢复了脂质分布和血管功能。这些作用伴随着炎症和氧化应激的减少。
In this study, we investigate the effect of lomitapide, a microsomal triglyceride transfer protein inhibitor, on the cardiovascular function in obesity. Eight-week-old C57BL/6 mice were fed with high fat diet (HFD) for 12 weeks in the presence and absence of lomitapide. Lomitapide was administered by gavage (1mg/Kg/Day) during the last 2 weeks of HFD feeding. Bodyweight, blood glucose, body composition, and lipid profile were determined. Vascular function and endothelial function markers were studied in the aorta and mesenteric resistance arteries (MRA). Lomitapide treatment reduced the body weight in mice with obesity. Blood glucose, % of fat mass, total cholesterol, and LDL levels were significantly reduced, and the % of lean mass was significantly increased after lomitapide treatment. Aortic and mesenteric arteries vascular response to sodium nitroprusside (SNP) was similar among groups. However, the vascular response to acetylcholine (Ach) was improved in the treated group. This was associated with decreased levels of vascular endoplasmic reticulum (ER) stress, inflammation, and oxidative stress. Treatment with lomitapide attenuated the increase in body weight in mice with obesity and restored the lipid profile and vascular function. These effects were accompanied by a decrease in inflammation and oxidative stress.
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影响因子：
158.5
作者：
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通讯作者：
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