Bimodal Nanocomposite Platform with Antibiofilm and Self-Powering Functionalities for Biomedical Applications.
Bimodal Nanocomposite Platform with Antibiofilm and Self-Powering Functionalities for Biomedical Applications.
复制标题
具有抗生物膜和自供电功能的生物医学应用双峰纳米复合材料平台。
DOI：
10.1021/acsami.1c11791
复制
发表时间：
2021-09-01
影响因子：
9.5
通讯作者：
Hwang G
中科院分区：
文献类型：
--
作者：
Dhall A;Islam S;Park M;Zhang Y;Kim A;Hwang G
微电子学和纳米纤维学的进步导致了可植入生物材料的发展。然而，医疗器械上的生物膜相关感染是严重破坏生物材料系统的临床适用性和进步的主要障碍。鉴于其有吸引力的压电行为，BTO基材料也已用于生物应用。尽管其多功能性，BTO包埋生物材料作为抗感染植入式医疗器械在人体内的可行性尚未探索。在这里，临床上可行的BTO-纳米复合材料的第一个演示。它表现出有效的抗变形链球菌的抗菌膜特性，而没有杀菌作用，同时保留了它们的压电和机械行为。这种抗粘附作用导致体外集落形成单位减少>10倍。为了阐明这种效应的潜在机制，描述BTO纳米复合材料和S之间的不利相互作用能量分布的数据。变形使用扩展的Derjaguin，朗道，Verwey，和Overbeek理论。使用原子力显微镜的直接细胞与表面结合力数据也证实了BTO纳米复合材料与S.变种人有趣的是，BTO-纳米复合材料的极化过程导致每一侧的表面电荷密度不对称，这可能有助于解决假体中的两个主要问题-细菌污染和组织整合。最后，BTO-纳米复合材料对人牙龈成纤维细胞和角质形成细胞表现出上级生物相容性。总的来说，BTO嵌入式复合材料表现出广泛的潜力，可用于生物环境中的能量收集的生物膜表面。
Advances in microelectronics and nanofabrication have led to the development of implantable biomaterials. However, biofilm-associated infection on medical devices is a major hurdle that substantially undermines the clinical applicability and advancement of biomaterial systems. Given their attractive piezoelectric behavior, BTO-based materials have also been used in biological applications. Despite its versatility, the feasibility of BTO-embedded biomaterials as anti-infectious implantable medical devices in the human body has not been explored yet. Here, the first demonstration of clinically viable BTO-nanocomposites is presented. It demonstrates potent antibiofilm properties against Streptococcus mutans without bactericidal effect while retaining their piezoelectric and mechanical behaviors. This anti-adhesive effect led to >10-fold reduction in colony-forming units in vitro. To elucidate the underlying mechanism for this effect, data depicting unfavorable interaction energy profiles between BTO-nanocomposites and S. mutans using the extended-Derjaguin, Landau, Verwey, and Overbeek theory is presented. Direct cell-to-surface binding force data using atomic force microscopy also corroborate reduced adhesion between BTO-nanocomposites and S. mutans. Interestingly, poling process on BTO-nanocomposites resulted in asymmetrical surface charge density on each side, which may help tackle two major issues in prosthetics- bacterial contamination and tissue integration. Finally, BTO-nanocomposites exhibit superior biocompatibility towards human gingival fibroblasts and keratinocytes. Overall, BTO-embedded composites exhibit the broad-scale potential to be used in biological settings as energy-harvestable antibiofilm surfaces.
登录
查看更多内容
影响因子：
9.5
作者：
Hwang, Geelsu;Koltisko, Bernard;Koo, Hyun
通讯作者：
Koo, Hyun
DOI：
10.1007/s10856-015-5619-8
发表时间：
2016-01
期刊：
Journal of materials science. Materials in medicine
影响因子：
--
作者：
Griffin MF;Premakumar Y;Seifalian AM;Szarko M;Butler PE
通讯作者：
Butler PE
影响因子：
3.7
作者：
Hwang, Geelsu;Yang, Ji-hyun;Mhin, Byung Jin
通讯作者：
Mhin, Byung Jin
影响因子：
5.7
作者：
Kim HE;Liu Y;Dhall A;Bawazir M;Koo H;Hwang G
通讯作者：
Hwang G
影响因子：
1.6
作者：
Hermanowicz, Pawel;Sarna, Michal;Gabrys, Halina
通讯作者：
Gabrys, Halina