Urinary NNAL in hookah smokers and non-smokers after attending a hookah social event in a hookah lounge or a private home.
Urinary NNAL in hookah smokers and non-smokers after attending a hookah social event in a hookah lounge or a private home.
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DOI：
10.1016/j.yrtph.2017.07.009
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发表时间：
2017-10
期刊：
影响因子：
--
通讯作者：
Hovell MF
中科院分区：
文献类型：
--
作者：
Kassem NOF;Kassem NO;Liles S;Jackson SR;Chatfield DA;Jacob P 3rd;Benowitz NL;Hovell MF
吸烟和接触烟草二手烟（SHS）可导致肺癌。我们测定了水烟吸烟者和暴露于水烟烟草SHS的非吸烟者对NNK（4-（甲基亚硝胺）-1-（3-吡啶基）-1-丁酮）（一种烟草特异性强效肺致癌物）的摄取。我们分析了201名居住在加州圣地亚哥县的成年（年龄≥18岁）纯水烟吸烟者（n=99）和非吸烟者（n=102）的社区便利样本的数据。参与者平均连续三个小时呆在室内，在水烟室或私人家中，在那里只抽水烟。总NNAL [4-（甲基亚硝胺基）-1-（3-吡啶基）-1-丁醇（NNAL）及其葡萄糖醛酸苷的总和]（NNK的主要代谢产物）在参加水烟活动当天早晨和次日早晨提供的现场尿样中进行定量。在水烟吸烟者中，水烟社交活动后尿NNAL显著增加（p<0.001）;几何平均值加倍，从1.97增加到4.16 pg/mg。在非吸烟者中，增加不显著（p=0.059）。水烟事件后尿NNAL水平在每日水烟吸烟者中最高，并且显著高于非每日吸烟者或非吸烟者（GM：分别为14.96 pg/mg vs. 3.13 pg/mg和0.67 pg/mg）。对于水烟吸烟者和非吸烟者，水烟休息室和家中的尿NNAL事件前后变化无显著差异。我们建议在水烟休息室内张贴健康警告标志，并鼓励在私人家中自愿禁止吸烟。
Tobacco smoking and exposure to tobacco secondhand smoke (SHS) can cause lung cancer. We determined uptake of NNK (4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone), a tobacco specific potent pulmonary carcinogen, in hookah smokers and non-smokers exposed to hookah tobacco SHS. We analyzed data from a community-based convenience sample of 201 of adult (aged ≥18 years) exclusive hookah smokers (n=99) and non-smokers (n=102) residing in San Diego County, California. Participants spent an average of three consecutive hours indoors, in hookah lounges or private homes, where hookah tobacco was smoked exclusively. Total NNAL [the sum of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronides], the major metabolites of NNK, were quantified in spot urine samples provided the morning of and the morning after attending a hookah event. Among hookah smokers urinary NNAL increased significantly (p<0.001) following a hookah social event; the geometric mean doubled, from 1.97 to 4.16 pg/mg. Among non-smokers the increase was not significant (p=0.059). Post hookah event urinary NNAL levels were highest in daily hookah smokers, and significantly higher than in non-daily smokers or non-smokers (GM: 14.96 pg/mg vs. 3.13 pg/mg and 0.67 pg/mg, respectively). For both hookah smokers and non-smokers, pre-to-post event change in urinary NNAL was not significantly different between hookah lounges and homes. We suggest posting health warning signs inside hookah lounges, and encouraging voluntary bans of smoking hookah tobacco in private homes.
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DOI：
10.1158/1055-9965.epi-09-0874
发表时间：
2009-12
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
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DOI：
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发表时间：
2013-05
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
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作者：
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影响因子：
7.4
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2.3
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