Effect of antioxidants and B-group vitamins on risk of infections in patients with type 2 diabetes mellitus.
Effect of antioxidants and B-group vitamins on risk of infections in patients with type 2 diabetes mellitus.
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DOI：
10.3390/nu5030711
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发表时间：
2013-03-05
期刊：
影响因子：
5.9
通讯作者：
Alessa A
中科院分区：
文献类型：
--
作者：
Gariballa S;Afandi B;Abu Haltem M;Yassin J;Alessa A
先前的研究表明，糖尿病患者免疫力下降，感染风险增加，这可能与微量营养素状况不良有关。本研究的目的是测量膳食补充剂对2型糖尿病患者感染风险的影响。100例2型糖尿病患者被随机分配接受每日口服剂量的B族维生素和抗氧化维生素（n = 50）或相同的安慰剂（n = 50），每日90天。对患者进行基线、3个月和12个月的营养状况、水果和蔬菜摄入、体力活动和自我报告的感染评估。在干预组中，补充抗氧化剂和B族维生素显著增加了维生素E和叶酸的血浆浓度，降低了同型半胱氨酸（p值分别为0.006、0.001和0.657）。治疗组在补充三个月后报告的感染数量少于安慰剂组，9（27%）对15（36%）（p = 0.623）。12个月时相应的感染数量分别为25例（67.5%）和27例（56.3%）（p = 0.488）。高达90%的糖尿病患者超重或肥胖，生活方式久坐不动，在三个月的随访期间，他们的体重进一步增加。该研究表明，多种维生素补充剂改善了维生素血液浓度;然而，这并没有减少糖尿病患者的感染数量。
Previous studies have revealed that diabetic patients have a decline in immunity and an increased risk of infections, and this may be associated with poor micronutrient status. The aim of this study was to measure the effect of dietary supplements on risk of infection in patients with type 2 diabetes mellitus. One hundred patients with type 2 diabetes mellitus were randomly assigned to receive an oral dose of daily B-group vitamins and antioxidant vitamins (n = 50) or an identical placebo (n = 50) daily for 90 days. Patients had baseline, three and 12 month assessment for nutritional status, fruits and vegetables intake, physical activity and self-reported infections. Supplementation with antioxidants and B-group vitamins significantly increased the plasma concentration of vitamin E and folate and reduced homocysteine in the intervention group (p-values were 0.006, 0.001 and 0.657, respectively). The number of infections reported by the treatment group after three months of supplements was less than that reported by the placebo group, 9 (27%) vs. 15 (36%) (p = 0.623). Corresponding numbers of infections at 12 months were 25 (67.5%) and 27 (56.3%), respectively (p = 0.488). Up to 90% of the diabetic patients were either overweight or obese with a sedentary life style, and their body weight increased further during three months of follow up. The study showed that multivitamin supplements improved vitamin blood concentrations; however, this did not reduce the number of infections in diabetic patients.
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影响因子：
120.7
作者：
Meydani, SN;Meydani, M;Stollar, BD
通讯作者：
Stollar, BD
影响因子：
7.7
作者：
MACCUISH, AC;URBANIAK, SJ;IRVINE, WJ
通讯作者：
IRVINE, WJ
影响因子：
7.1
作者：
BOGDEN, JD;BENDICH, A;LOURIA, DB
通讯作者：
LOURIA, DB
影响因子：
2.1
作者：
De la Fuente, M;Ferrández, MD;Miquel, J
通讯作者：
Miquel, J
影响因子：
16.2
作者：
BRYAN, CS;REYNOLDS, KL;METZGER, WT
通讯作者：
METZGER, WT