Urinary metabolite profiles in premature infants show early postnatal metabolic adaptation and maturation.
Urinary metabolite profiles in premature infants show early postnatal metabolic adaptation and maturation.
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DOI：
10.3390/nu6051913
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发表时间：
2014-05-12
期刊：
影响因子：
5.9
通讯作者：
Drevon CA
中科院分区：
文献类型：
--
作者：
Moltu SJ;Sachse D;Blakstad EW;Strømmen K;Nakstad B;Almaas AN;Westerberg AC;Rønnestad A;Brække K;Veierød MB;Iversen PO;Rise F;Berg JP;Drevon CA
目的：早期营养影响代谢规划和长期健康。我们探讨了48名早产儿（出生体重< 1500 g）在新生儿住院期间随机接受强化或标准饮食的尿代谢产物谱。研究方法：使用核磁共振光谱法（NMR）对出生后第一周和此后每两周获得的尿样进行代谢组学研究。结果如下：与对照组相比，干预组接受的能量、蛋白质、脂质、维生素A、花生四烯酸和二十二碳六烯酸的量明显更高。加强营养似乎并没有影响尿液的个人差异超过的程度。然而，在所有婴儿中，生糖氨基酸甘氨酸、苏氨酸、羟脯氨酸和酪氨酸在出生后早期显著增加，沿着增加的还有三羧酸循环的代谢物（琥珀酸、酮戊二酸、富马酸和柠檬酸）。代谢物的变化与月经后年龄相关。此外，与适合胎龄的婴儿相比，我们观察到小于胎龄儿（SGA;出生体重<胎龄第10百分位数）的第一周尿样中苏氨酸和甘氨酸水平升高。结论：这项针对早产儿的首次营养代谢组学研究表明，胎儿-产后过渡期的生理适应以及成熟会影响母乳喂养期间的代谢。在SGA婴儿的第一周尿样中发现甘氨酸和苏氨酸水平升高，并作为代谢表型改变的潜在生物标志物出现。
Objectives: Early nutrition influences metabolic programming and long-term health. We explored the urinary metabolite profiles of 48 premature infants (birth weight < 1500 g) randomized to an enhanced or a standard diet during neonatal hospitalization. Methods: Metabolomics using nuclear magnetic resonance spectroscopy (NMR) was conducted on urine samples obtained during the first week of life and thereafter fortnightly. Results: The intervention group received significantly higher amounts of energy, protein, lipids, vitamin A, arachidonic acid and docosahexaenoic acid as compared to the control group. Enhanced nutrition did not appear to affect the urine profiles to an extent exceeding individual variation. However, in all infants the glucogenic amino acids glycine, threonine, hydroxyproline and tyrosine increased substantially during the early postnatal period, along with metabolites of the tricarboxylic acid cycle (succinate, oxoglutarate, fumarate and citrate). The metabolite changes correlated with postmenstrual age. Moreover, we observed elevated threonine and glycine levels in first-week urine samples of the small for gestational age (SGA; birth weight < 10th percentile for gestational age) as compared to the appropriate for gestational age infants. Conclusion: This first nutri-metabolomics study in premature infants demonstrates that the physiological adaptation during the fetal-postnatal transition as well as maturation influences metabolism during the breastfeeding period. Elevated glycine and threonine levels were found in the first week urine samples of the SGA infants and emerged as potential biomarkers of an altered metabolic phenotype.
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DOI：
10.1016/0002-9378(89)90670-4
发表时间：
1989-11-01
影响因子：
9.8
作者：
ECONOMIDES, DL;NICOLAIDES, KH;EVANS, MI
通讯作者：
EVANS, MI
影响因子：
7
作者：
Koletzko, Berthold;Brands, Brigitte;Demmelmair, Hans
通讯作者：
Demmelmair, Hans
影响因子：
2.7
作者：
DEVRIES, LS;EKEN, P;DUBOWITZ, LMS
通讯作者：
DUBOWITZ, LMS
影响因子：
5.1
作者：
Lapillonne, Alexandre;O'Connor, Deborah L.;Rigo, Jacques
通讯作者：
Rigo, Jacques
DOI：
10.1038/sj.jp.7211308
发表时间：
2005-05-01
期刊：
Journal of perinatology : official journal of the California Perinatal Association
影响因子：
--
作者：
Lucas, Alan
通讯作者：
Lucas, Alan