Relationship between urinary phthalate and bisphenol A concentrations and serum thyroid measures in U.S. adults and adolescents from the National Health and Nutrition Examination Survey (NHANES) 2007-2008.
Relationship between urinary phthalate and bisphenol A concentrations and serum thyroid measures in U.S. adults and adolescents from the National Health and Nutrition Examination Survey (NHANES) 2007-2008.
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邻苯二甲酸盐和双苯酚A浓度与血清甲状腺甲状腺措施之间的关系，来自国家健康与营养检查调查（NHANES）2007-2008之间的关系。
DOI：
10.1289/ehp.1103582
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发表时间：
2011-10
影响因子：
10.4
通讯作者：
Ferguson KK
中科院分区：
文献类型：
--
作者：
Meeker JD;Ferguson KK
背景：有限的动物、体外和人体研究报告称，接触邻苯二甲酸酯或双酚A（BPA）可能会影响甲状腺信号传导。目的：我们在美国成年人和青少年的代表性样本中探索了邻苯二甲酸二（2-乙基己基）酯（DEHP）、邻苯二甲酸二丁酯（DBP）和BPA代谢物的尿液浓度与一组血清甲状腺测量值之间的横断面关系。研究方法：我们使用多变量线性回归分析了2007-2008年国家健康和营养调查（NHANES）中1,346名成人（年龄≥ 20岁）和329名青少年（年龄12-19岁）暴露于邻苯二甲酸酯和BPA的尿液生物标志物、血清甲状腺指标和重要协变量的数据。结果如下：在成人中，我们观察到尿DEHP代谢物与总甲状腺素（T4）、游离T4、总三碘甲状腺原氨酸（T3）和甲状腺球蛋白之间存在显著的负相关关系，与促甲状腺激素（TSH）呈正相关关系。最强和最一致的关系涉及总T4，其中氧化DEHP代谢物五分位数的调整回归系数显示总T4呈单调剂量依赖性降低（趋势p值< 0.0001）。尿BPA与总T_4和TSH呈负相关。相反，在青少年中，我们观察到DEHP代谢物与总T3之间存在显著的正相关关系。邻苯二甲酸单（3-羧丙基）酯（DBP和邻苯二甲酸二正辛酯的次级代谢产物）与两个年龄组中的几项甲状腺指标相关，而其他DBP代谢产物与甲状腺指标无关。结论：这些结果支持了以前关于邻苯二甲酸酯（可能还有BPA）与甲状腺激素改变之间的关系的报道。需要更详细的研究来确定这些关联的时间关系和潜在的临床和公共卫生影响。
Background: Limited animal, in vitro, and human studies have reported that exposure to phthalates or bisphenol A (BPA) may affect thyroid signaling. Objective: We explored the cross-sectional relationship between urinary concentrations of metabolites of di(2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and BPA with a panel of serum thyroid measures among a representative sample of U.S. adults and adolescents. Methods: We analyzed data on urinary biomarkers of exposure to phthalates and BPA, serum thyroid measures, and important covariates from 1,346 adults (ages ≥ 20 years) and 329 adolescents (ages 12–19 years) from the National Health and Nutrition Examination Survey (NHANES) 2007–2008 using multivariable linear regression. Results: Among adults, we observed significant inverse relationships between urinary DEHP metabolites and total thyroxine (T4), free T4, total triiodothyronine (T3), and thyroglobulin, and positive relationships with thyroid-stimulating hormone (TSH). The strongest and most consistent relationships involved total T4, where adjusted regression coefficients for quintiles of oxidative DEHP metabolites displayed monotonic dose-dependent decreases in total T4 (p-value for trend < 0.0001). Suggestive inverse relationships between urinary BPA and total T4 and TSH were also observed. Conversely, among adolescents, we observed significant positive relationships between DEHP metabolites and total T3. Mono(3-carboxypropyl) phthalate, a secondary metabolite of both DBP and di-n-octyl phthalate, was associated with several thyroid measures in both age groups, whereas other DBP metabolites were not associated with thyroid measures. Conclusions: These results support previous reports of associations between phthalates—and possibly BPA—and altered thyroid hormones. More detailed studies are needed to determine the temporal relationships and potential clinical and public health implications of these associations.
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影响因子：
10.4
作者：
Braun JM;Yolton K;Dietrich KN;Hornung R;Ye X;Calafat AM;Lanphear BP
通讯作者：
Lanphear BP
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影响因子：
10.4
作者：
Mahalingaiah, Shruthi;Meeker, John D.;Pearson, Kimberly R.;Calafat, Antonia M.;Ye, Xiaoyun;Petrozza, John;Hauser, Russ
通讯作者：
Hauser, Russ
影响因子：
10.4
作者：
HINTON, RH;MITCHELL, FE;BRIDGES, JW
通讯作者：
BRIDGES, JW
影响因子：
4.1
作者：
Breous, E;Wenzel, A;Loos, U
通讯作者：
Loos, U
影响因子：
10.4
作者：
Cho SC;Bhang SY;Hong YC;Shin MS;Kim BN;Kim JW;Yoo HJ;Cho IH;Kim HW
通讯作者：
Kim HW