Coordination-Responsive Longitudinal Relaxation Tuning as a Versatile MRI Sensing Protocol for Malignancy Targets.
Coordination-Responsive Longitudinal Relaxation Tuning as a Versatile MRI Sensing Protocol for Malignancy Targets.
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协调响应纵向弛豫调谐作为恶性肿瘤目标的多功能 MRI 传感协议
DOI：
10.1002/advs.201800021
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Zhao Y
中科院分区：
文献类型：
--
作者：
Zhang K;Cheng Y;Ren W;Sun L;Liu C;Wang D;Guo L;Xu H;Zhao Y
生物标志物(如酸度、过氧化氢、缺氧、特定分子等)作为肿瘤微环境的主要组成部分，与肿瘤的发生、侵袭和转移密切相关，可作为肿瘤的生物学靶点。然而，对它们的监测仍然是一项具有挑战性的任务。在这里，建立了发生在Mn2+“施主”和Mn2+“受体”之间的配位依赖的纵向弛豫调谐(CLRT)，以实现生物靶标的传感。由于供体和受体之间的配位能力和空间结构的差异，作为Mn2+受体的生物靶标可以在纳米尺度的探针中将Mn2+从供体(即修饰配体)中带走，从而改变T1加权磁共振成像(T1W)信号。证明了修饰后的Mn2+“给体”的配位能力和空间结构以及给体载体的孔径，从而确定了CLRT的可行性、特异性和通用性。通过CLRT，这种基于MRI的标尺成功地特异性地检测了恶性肿瘤的生物靶点(即透明质酸和谷胱甘肽)，并进一步展示了其在透明质酸定量测量中的潜力。CLRT可以作为一种新的和通用的传感原理来增强对广泛的生物系统的探索。
Biomarkers (e.g., acidity, H2O2, hypoxia, and specific molecules) as one primary component of tumor microenvironments are closely associated with occurrence, invasion, and metastasis of malignancy, thus can act as biological targets. However, their monitoring remains a challenging task. Herein, a coordination‐dependent longitudinal relaxation tuning (CLRT) that occurs between a Mn2+ “donor” and a Mn2+ “acceptor” is established to enable biological target sensing. Relying on the differences of coordination ability and spatial structure between donors and acceptors, the biological targets as Mn2+ acceptor can take Mn2+ away from the donors (i.e., modified ligands) in nanoscale probes, which consequently varies T1‐weighted (T1W) magnetic resonance imaging (MRI) signal. The coordination ability and spatial structure of the modified Mn2+ “donor” and the pore diameter of donor carrier are demonstrated to determine the feasibility, specificity, and generality of CLRT. With CLRT, this MRI‐based ruler is demonstrated for the successful specific detection of biological targets (i.e., hyaluronic acid and glutathione) of malignancy, and its potential in quantitative measurement of hyaluronic acid is further demonstrated. CLRT can serve as a novel and general sensing principle to augment the exploration of a wide range of biological systems.
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