Working hard for oneself or others: Effects of oxytocin on reward motivation in social anxiety disorder.
Working hard for oneself or others: Effects of oxytocin on reward motivation in social anxiety disorder.
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DOI：
10.1016/j.biopsycho.2017.05.015
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发表时间：
2017-07
影响因子：
2.6
通讯作者：
Hofmann SG
中科院分区：
文献类型：
--
作者：
Fang A;Treadway MT;Hofmann SG
有一些证据表明，催产素促进社会行为，特别是对以社会功能障碍为特征的疾病，如社交焦虑症（SAD）。本研究旨在探讨催产素对SAD患者奖励动机的影响。我们测试了催产素是否会促进亲社会或反社会的自我导向决策，以及它的影响是否取决于社交焦虑的严重程度和依恋。52名患有SAD的男性接受了24个国际单位的催产素或安慰剂，并完成了一项奖励激励任务，该任务测量了为自己工作的意愿与其他金钱奖励。虽然没有主要的药物作用，社交焦虑的严重程度缓和催产素的效果。与高社交焦虑的人相比，接受催产素的社交焦虑程度较低的人更努力地为他人而不是自己的奖励工作。依恋没有缓和这种影响。在SAD患者中，催产素增强了社交焦虑水平相对较低的个体的亲社会行为。美国国立卫生研究院ClinicalTrials.gov注册号NCT01856530。https://clinicaltrials.gov/ct2/show/NCT01856530?术语=催产素+亲社会&等级=2。
There is some evidence to suggest that oxytocin promotes social behavior, especially for disorders characterized by social dysfunction, such as social anxiety disorder (SAD). The goal of this study was to examine the effect of oxytocin on reward motivation in SAD. We tested whether oxytocin promotes prosocial, or antisocial, self-directed decisions, and whether its effects depended on social anxiety severity and attachment. Fifty-two males with SAD received 24 international units of oxytocin or placebo, and completed a reward motivation task that measured willingness to work for self vs. other monetary rewards. Although there was no main drug effect, social anxiety severity moderated the effect of oxytocin. Less socially anxious individuals who received oxytocin worked harder for other vs. own rewards, compared to high socially anxious individuals. Attachment did not moderate this effect. Among people with SAD, oxytocin enhances prosocial behaviors in individuals with relatively lower levels of social anxiety. National Institutes of Health ClinicalTrials.gov Registry #NCT01856530. https://clinicaltrials.gov/ct2/show/NCT01856530?term=oxytocin+pro-social&rank=2.
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