fMRI of alterations in reward selection, anticipation, and feedback in major depressive disorder.
fMRI of alterations in reward selection, anticipation, and feedback in major depressive disorder.
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DOI：
10.1016/j.jad.2009.01.034
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发表时间：
2009-11
影响因子：
6.6
通讯作者：
Dichter, Gabriel S.
中科院分区：
文献类型：
--
作者：
Smoski, Moria J.;Felder, Jennifer;Bizzell, Joshua;Green, Steven R.;Ernst, Monique;Lynch, Thomas R.;Dichter, Gabriel S.
关键词：
本研究旨在探讨单相抑郁障碍（MDD）患者的奖赏加工特点。具体来说，我们调查了成年MDD患者是否表现出纹状体脑区的低反应性和/或皮质脑区的高反应性，这些脑区涉及使用命运之轮任务来探测奖励选择，奖励预期和奖励反馈过程中的反应。功能性磁共振成像（fMRI）数据表明，MDD组的特点是减少激活纹状体奖励区域在奖励选择，奖励预期，奖励反馈，支持以前的数据表明在MDD的奖励系统的低反应。没有发现支持奖励选择或奖励预期过程中的认知控制区域的高反应性。相反，MDD参与者在奖励选择过程中表现出眶额皮层的高反应性，这是一个与风险和奖励评估相关的区域，在奖励选择和预期过程中，额中回和扣带回的激活减少。最后，抑郁的严重程度预测在奖励选择过程中激活双侧额中回。结果表明，抑郁症的特点是纹状体hyporesponsivity，和未来的研究，寻求改善反应的奖励刺激抑郁症的治疗应评估纹状体功能。
The purpose of the present investigation was to evaluate reward processing in unipolar major depressive disorder (MDD). Specifically, we investigated whether adults with MDD demonstrated hyporesponsivity in striatal brain regions and/or hyperresponsivity in cortical brain regions involved in conflict monitoring using a Wheel of Fortune task designed to probe responses during reward selection, reward anticipation, and reward feedback. Functional magnetic resonance imaging (fMRI) data indicated that the MDD group was characterized by reduced activation of striatal reward regions during reward selection, reward anticipation, and reward feedback, supporting previous data indicating hyporesponsivity of reward systems in MDD. Support was not found for hyperresponsivity of cognitive control regions during reward selection or reward anticipation. Instead, MDD participants showed hyperresponsivity in orbitofrontal cortex, a region associated with assessment of risk and reward, during reward selection, as well as decreased activation of the middle frontal gyrus and the rostral cingulate gyrus during reward selection and anticipation. Finally, depression severity was predicted by activation in bilateral midfrontal gyrus during reward selection. Results indicate that MDD is characterized by striatal hyporesponsivity, and that future studies of MDD treatments that seek to improve responses to rewarding stimuli should assess striatal functioning.
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影响因子：
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作者：
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