Relationships between values of antibodies to several connective tissue disease autoantigens and pulmonary function in a Japanese general population: the Takahata study.
Relationships between values of antibodies to several connective tissue disease autoantigens and pulmonary function in a Japanese general population: the Takahata study.
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DOI：
10.1371/journal.pone.0081678
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Kubota I
中科院分区：
文献类型：
--
作者：
Nakano H;Shibata Y;Inoue S;Igarashi A;Yamauchi K;Abe S;Sato M;Aida Y;Nunomiya K;Kimura T;Nemoto T;Watanabe T;Konta T;Ueno Y;Kato T;Kayama T;Kubota I
越来越多的证据表明，呼吸功能障碍的发病机制中的自身免疫机制的参与。本研究的目的是调查肺功能和血清抗体的几个结缔组织病自身抗原（ACTDA）水平，这还没有在一般人群中进行了研究之间的关系。对2004年至2006年期间在日本Takahata参加基于社区的年度健康检查的年龄≥40岁的受试者（n = 3，257）进行血样采集和肺功能测定。采用酶免疫法测定ACTDA，ACTDA值≥20的受试者定义为阳性。在男性中，经数学转换的ACTDA值与肺功能参数（包括1 s用力呼气量（FEV 1）和最大呼气中段流量（MMF）以及FEV 1/用力肺活量（FVC）的%预测值）之间存在显著的负相关关系。多元线性回归分析显示，除了ACTDA和FEV 1/FVC之间的关系外，这些关系在调整Brinkman指数（一种吸入香烟消费量的测量方法）后仍然显着。阳性ACTDA的患病率在有混合性通气障碍和相对严重的气流阻塞（%预测FEV 1低于中位数）的男性从不吸烟者中更高。在一般人群中，自身免疫可能参与肺功能受损的机制。
Accumulating evidence suggests the involvement of an autoimmune mechanism in the pathogenesis of respiratory dysfunction. The aim of this study was to investigate the relationship between pulmonary function and serum antibodies to several connective tissue disease autoantigens (ACTDA) levels, which has not been investigated in a general population. Blood sampling and spirometry were performed for subjects (n = 3,257) aged ≥40 years who participated in a community-based annual health check in Takahata, Japan, from 2004 to 2006. ACTDA was measured by enzyme immunoassay, and subjects with ACTDA values ≥20 were defined as positive. In males, there were significant inverse relationships between logarithmically transformed ACTDA values and spirometric parameters, including % predicted values for forced expiratory volume in 1 s (FEV1) and maximal midexpiratory flow (MMF) as well as FEV1/forced vital capacity (FVC). Multiple linear regression analysis revealed that except for the relationship between ACTDA and FEV1/FVC, these relationships were still significant after adjustment for Brinkman index (a measure of inhaled cigarette consumption). The prevalence of positive ACTDA was greater in male never-smokers with mixed ventilation disorders and relatively severe airflow obstruction (% predicted FEV1 below the median value). Autoimmunity may be involved in the mechanism of impaired pulmonary function in the general population.
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影响因子：
5.8
作者：
Agusti A;Calverley PM;Celli B;Coxson HO;Edwards LD;Lomas DA;MacNee W;Miller BE;Rennard S;Silverman EK;Tal-Singer R;Wouters E;Yates JC;Vestbo J;Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators
通讯作者：
Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators
影响因子：
3.6
作者：
Aida Y;Shibata Y;Osaka D;Abe S;Inoue S;Fukuzaki K;Tokairin Y;Igarashi A;Yamauchi K;Nemoto T;Nunomiya K;Kishi H;Sato M;Watanabe T;Konta T;Kawata S;Kato T;Kubota I
通讯作者：
Kubota I
DOI：
10.1164/rccm.201010-1605oc
发表时间：
2011-10-01
影响因子：
24.7
作者：
Kirkham, Paul A.;Caramori, Gaetano;Adcock, Ian M.
通讯作者：
Adcock, Ian M.
DOI：
10.1164/rccm.201001-0029oc
发表时间：
2011-04-15
影响因子：
24.7
作者：
Nunez, Belen;Sauleda, Jaume;Agusti, Alvar
通讯作者：
Agusti, Alvar
影响因子：
15.9
作者：
Kasahara, Y;Tuder, RM;Voelkel, NF
通讯作者：
Voelkel, NF