Untemplated Resveratrol-Mediated Polydopamine Nanocapsule Formation.
Untemplated Resveratrol-Mediated Polydopamine Nanocapsule Formation.
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DOI：
10.1021/acsami.8b14128
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发表时间：
2018-10-10
影响因子：
9.5
通讯作者：
Messersmith PB
中科院分区：
文献类型：
--
作者：
Amin DR;Higginson CJ;Korpusik AB;Gonthier AR;Messersmith PB
纳米胶囊可设计用于药物输送、催化和生物成像等应用。贻贝启发的材料聚多巴胺是一个有前途的壳层纳米胶囊，因为它的自由基清除能力，能够与广泛的功能分子，缺乏毒性和生物降解性的反应。PDA纳米胶囊形成的先前报道依赖于模板方法。在此，我们报告了一种无模板的方法，在白藜芦醇的存在下，聚多巴胺纳米胶囊的形成，白藜芦醇是一种天然存在的抗炎和抗氧化化合物，发现在红葡萄酒和葡萄。在pH 8.5的白藜芦醇/多巴胺·盐酸乙醇溶液中自发合成纳米胶囊。紫外-可见吸收光谱和X射线光电子能谱表明，白藜芦醇被纳入纳米胶囊。我们还观察到在合成过程中形成可溶性荧光多巴胺-白藜芦醇加合物，通过HPLC，UV-Vis光谱和ESI-MS进行鉴定。使用TEM和DLS，我们研究了溶剂组成，多巴胺浓度和白藜芦醇：多巴胺比对纳米胶囊直径和壳厚度的影响。所得纳米胶囊具有优异的自由基清除活性，如通过DPPH自由基清除测定所测量的。我们的工作提供了一个方便的途径，通过该途径RV和可能的其他疏水生物活性化合物可以被封装在聚多巴胺纳米胶囊内。
Nanocapsules can be designed for applications including drug delivery, catalysis, and biological imaging. The mussel-inspired material polydopamine is a promising shell layer for nanocapsules because of its free radical scavenging capacity, ability to react with a broad range of functional molecules, lack of toxicity, and biodegradability. Previous reports of PDA nanocapsule formation have relied on a templating approach. Herein, we report a template-free approach to polydopamine nanocapsule formation in the presence of resveratrol, a naturally occurring anti-inflammatory and antioxidant compound found in red wine and grapes. Synthesis of nanocapsules occurs spontaneously in an ethanolic resveratrol/dopamine·HCl solution at pH 8.5. UV-Vis absorbance spectroscopy and X-ray photoelectron spectroscopy indicate that resveratrol is incorporated into the nanocapsules. We also observed the formation of a soluble fluorescent dopamine-resveratrol adduct during synthesis which was identified by HPLC, UV-Vis spectroscopy, and ESI-MS. Using TEM and DLS, we studied the influence of solvent composition, dopamine concentration, and resveratrol:dopamine ratio on the nanocapsule diameter and shell thickness. The resulting nanocapsules have excellent free radical scavenging activity as measured by a DPPH radical scavenging assay. Our work provides a convenient pathway by which RV, and possibly other hydrophobic bioactive compounds, may be encapsulated within polydopamine nanocapsules.
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影响因子：
4.6
作者：
Liao N;Wu M;Pan F;Lin J;Li Z;Zhang D;Wang Y;Zheng Y;Peng J;Liu X;Liu J
通讯作者：
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影响因子：
10.9
作者：
Fei, Bin;Qian, Baitai;Xin, John H.
通讯作者：
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影响因子：
4.6
作者：
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通讯作者：
Zhou, Feng
影响因子：
64.8
作者：
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通讯作者：
Sinclair, David A.
影响因子：
18.2
作者：
Huang Y;Li Y;Hu Z;Yue X;Proetto MT;Jones Y;Gianneschi NC
通讯作者：
Gianneschi NC