Polybrominated diphenyl ether (PBDE) exposure in children: possible associations with cardiovascular and psychological functions.
Polybrominated diphenyl ether (PBDE) exposure in children: possible associations with cardiovascular and psychological functions.
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DOI：
10.1016/j.envres.2014.04.009
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发表时间：
2014-07
影响因子：
8.3
通讯作者：
Kannan, Kurunthachalam
中科院分区：
文献类型：
--
作者：
Gump, Brooks B.;Yun, Sehun;Kannan, Kurunthachalam
多溴联苯醚（PBDE）已被广泛用于消费品，目前在地球仪的人类和动物血液中发现了可检测水平的PBDE。与多溴二苯醚的广泛接触形成鲜明对比的是，关于儿童接触这些化学品可能对健康产生的不利影响的研究相对较少。我们进行了这项横断面研究，以确定血液中的多溴联苯醚水平（4种同系物）是否与儿童的心血管应激反应和心理状态有关。对儿童（N = 43）全血中4种多溴二苯醚同系物（BDE-28、-47、-99和-100）的水平进行了测量。这些水平与心血管疾病风险因素有关，包括心血管对急性应激的反应和相关的心理变量，即敌意和抑郁。血液中多溴联苯醚含量较高，在急性心理压力和愤怒情绪加剧时，交感神经活动明显增强，这一心理变量的3种不同测量方法之间存在显著关联。这项研究表明，多溴二苯醚接触与儿童对压力的心血管反应以及父母和儿童自我报告的愤怒之间存在关联。这些变量特别重要，因为它们可能与心血管疾病（CVD）的未来发展具有潜在相关性。虽然有趣，有必要进一步调查和复制更大的儿童样本。
Polybrominated diphenyl ethers (PBDE) have been used widely in consumer products and are currently found at detectable levels in the blood of humans and animals across the globe. In stark contrast to this widespread exposure to PBDEs, there is relatively little research on potential adverse health effects of exposure of children to these chemicals. We performed this cross-sectional study to determine if blood PBDE levels (for 4 congeners) are associated with cardiovascular stress responses and psychological states in children. Levels of 4 PBDE congeners (BDE-28, -47, -99, and -100) in whole blood were measured in children (N = 43). These levels were analyzed in relation to cardiovascular disease risk factors, including cardiovascular responses to acute stress and relevant psychological variables, namely, hostility and depression. Higher levels of blood PBDEs were associated with significantly greater sympathetic activation during acute psychological stress and greater anger, as evidenced by significant associations with 3 different measures of this psychological variable. This study suggests an association between PBDE exposure and children’s cardiovascular responses to stress as well as parental and self-reported anger in the child. These variables are particularly important as they may be of potential relevance to the future development of cardiovascular disease (CVD). Although intriguing, there is a need for further investigation and replication with a larger sample of children.
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DOI：
10.1291/hypres.18.99
发表时间：
1995-06-01
期刊：
Hypertension research : official journal of the Japanese Society of Hypertension
影响因子：
--
作者：
Amerena, J;Julius, S
通讯作者：
Julius, S
DOI：
10.1111/j.1749-6632.1970.tb17735.x
发表时间：
1970-01-01
影响因子：
5.2
作者：
KUBICEK, WG;PATTERSON, RP;WITSOE, DA
通讯作者：
WITSOE, DA
影响因子：
11.8
作者：
Gascon, Mireia;Vrijheid, Martine;Sunyer, Jordi
通讯作者：
Sunyer, Jordi
影响因子：
5.3
作者：
Balslev, D;Christensen, LOD;Miall, RC
通讯作者：
Miall, RC
影响因子：
3.4
作者：
Fitzgerald, Edward F.;Shrestha, Srishti;Hwang, Syni-an
通讯作者：
Hwang, Syni-an