Quantitative MRI and spectroscopy of bone marrow.
Quantitative MRI and spectroscopy of bone marrow.
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DOI：
10.1002/jmri.25769
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Baum T
中科院分区：
文献类型：
--
作者：
Karampinos DC;Ruschke S;Dieckmeyer M;Diefenbach M;Franz D;Gersing AS;Krug R;Baum T
骨髓是人体最大的器官之一，包含脂肪细胞、负责产生血细胞的造血干细胞和负责产生脂肪细胞和骨细胞的间充质干细胞。磁共振成像（MRI）由于其固有的丰富的软组织对比度，是监测健康和病理状态下骨髓变化的理想成像方式。还开发了定量骨髓 MRI 和磁共振波谱 (MRS) 技术，以量化不同病理状态下骨髓水脂肪成分、细胞结构和灌注的变化，并帮助了解骨髓在全身性疾病（例如骨质疏松症）病理生理学中的作用。本综述总结了截至 2017 年 3 月发表的大量关于基于质子的骨髓定量 MRI 和 MRS 的研究。首先回顾了有关骨髓解剖学和生理学的一些基本知识。然后描述了测量骨髓水脂肪成分、脂肪酸成分、灌注和扩散的定量 MR 方法最重要的技术方面。最后，回顾了以往的定量磁共振技术在健康老龄化和受骨质疏松、骨折、代谢性疾病、多发性骨髓瘤和骨转移影响的病变骨髓中的应用的磁共振研究。 证据级别：3 技术功效：第 2 阶段 J. Magn。共振。影像学 2018 年；47：332–353。
Bone marrow is one of the largest organs in the human body, enclosing adipocytes, hematopoietic stem cells, which are responsible for blood cell production, and mesenchymal stem cells, which are responsible for the production of adipocytes and bone cells. Magnetic resonance imaging (MRI) is the ideal imaging modality to monitor bone marrow changes in healthy and pathological states, thanks to its inherent rich soft‐tissue contrast. Quantitative bone marrow MRI and magnetic resonance spectroscopy (MRS) techniques have been also developed in order to quantify changes in bone marrow water–fat composition, cellularity and perfusion in different pathologies, and to assist in understanding the role of bone marrow in the pathophysiology of systemic diseases (e.g. osteoporosis). The present review summarizes a large selection of studies published until March 2017 in proton‐based quantitative MRI and MRS of bone marrow. Some basic knowledge about bone marrow anatomy and physiology is first reviewed. The most important technical aspects of quantitative MR methods measuring bone marrow water–fat composition, fatty acid composition, perfusion, and diffusion are then described. Finally, previous MR studies are reviewed on the application of quantitative MR techniques in both healthy aging and diseased bone marrow affected by osteoporosis, fractures, metabolic diseases, multiple myeloma, and bone metastases. Level of Evidence: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:332–353.
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DOI：
10.1038/oby.2010.106
发表时间：
2011-01
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Bredella MA;Torriani M;Ghomi RH;Thomas BJ;Brick DJ;Gerweck AV;Rosen CJ;Klibanski A;Miller KK
通讯作者：
Miller KK
影响因子：
6.2
作者：
Burge, Russel;Dawson-Hughes, Bess;Tosteson, Anna
通讯作者：
Tosteson, Anna
影响因子：
4.4
作者：
Bolan, Patrick J.;Arentsen, Luke;Sueblinvong, Thanasak;Zhang, Yan;Moeller, Steen;Carter, Jori S.;Downs, Levi S., Jr.;Ghebre, Rahel;Yee, Douglas;Froelich, Jerry;Hui, Susanta
通讯作者：
Hui, Susanta
影响因子：
2.6
作者：
Aoki, Takatoshi;Yamaguchi, Shinpei;Korogi, Yukunori
通讯作者：
Korogi, Yukunori
影响因子：
5.8
作者：
Bredella, Miriam A.;Fazeli, Pouneh K.;Klibanski, Anne
通讯作者：
Klibanski, Anne