Youth Team Sports Participation Associates With Reduced Dimensional Psychopathology Through Interaction With Biological Risk Factors.
Youth Team Sports Participation Associates With Reduced Dimensional Psychopathology Through Interaction With Biological Risk Factors.
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DOI：
10.1016/j.bpsgos.2023.02.001
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发表时间：
2023-10
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影响因子：
--
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中科院分区：
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在年轻人中，体力活动与心理健康益处有关。在这里，我们使用因果推断和两个生物学水平的三角测量来证实青少年参与运动和空间精神病理学之间的关系。青少年大脑认知发育(ABCD)研究招募了全美9至10岁的儿童，该研究的基线数据被包括在多水平回归模型中，以评估终身参与团队运动(TS)、个人运动和非体育活动与儿童行为检查表(CBCL)得分之间的关系。我们计算了8种精神疾病的多基因风险得分，以评估与运动暴露对欧洲后代CBCL得分的交互作用。遵循严格的质量控制，自由冲浪提取的脑磁共振成像结构数据被检查以调节CBCL-活动关系。在那些拥有完整数据(N=10,411)的人中，使用逆概率加权的因果估计与终生TS暴露与CBCL总数减少1.05点(95%CI，−1.54to−0.56p<；.0001)有关，这种关系是TS特有的，随着暴露年限的增加而加强。在有TS暴露的欧洲儿童中，注意缺陷/多动障碍多基因负荷与CBCL总量的相关性减弱(n=4041；β=−0.93，SE=0.38，p=.013)。此外，TS的参与和较低的CBCL均与皮质下体积的增加相关(n=8197)。皮质下体积介导了5.5%的TS对CBCL总量的影响。我们的发现通过额外的研究来支持先前在青少年中参与TS与较低的精神病理学之间的关联，这些研究证明了特异度、剂量反应和跨越两个生物学水平的一致性。进一步明确因果关系的纵向研究可能证明对高危青年进行TS的干预性研究是合理的。
Physical activity is associated with mental health benefits in youth. Here, we used causal inference and triangulation with 2 levels of biology to substantiate relationships between sports participation and dimensional psychopathology in youths. Baseline data from the Adolescent Brain Cognitive Development (ABCD) Study, which recruited children from 9 to 10 years of age across the United States, were included in multilevel regression models to assess relationships between lifetime participation in team sports (TS), individual sports, and nonsports activities and Child Behavior Checklist (CBCL) scores. We calculated polygenic risk scores for 8 psychiatric disorders to assess interactions with sports exposure on CBCL scores among European descendants. Following rigorous quality control, FreeSurfer-extracted brain magnetic resonance imaging structural data were examined for mediation of CBCL–activities relationships. Among those with complete data (N = 10,411), causal estimates using inverse probability weighting associated lifetime TS exposure with a 1.05-point reduction in CBCL total (95% CI, −1.54 to −0.56, p < .0001) a relationship that was specific to TS and strengthened with more years of exposure. Associations of attention-deficit/hyperactivity disorder polygenic loading with CBCL total weakened in European children with TS exposure (n = 4041; beta = −0.93, SE = 0.38, p = .013). Furthermore, TS participation and lower CBCL each associated with increased subcortical volumes (n = 8197). Subcortical volume mediated 5.5% of TS effects on CBCL total. Our findings support prior associations of TS participation with lower psychopathology in youths through additional studies that demonstrate specificity, dose response, and coherence across 2 levels of biology. Longitudinal studies that further clarify causal relationships may justify interventional studies of TS for high-risk youth.
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影响因子：
11
作者：
International Obsessive Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC) and OCD Collaborative Genetics Association Studies (OCGAS)
通讯作者：
International Obsessive Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC) and OCD Collaborative Genetics Association Studies (OCGAS)
影响因子：
2.9
作者：
Chaddock L;Erickson KI;Prakash RS;Kim JS;Voss MW;Vanpatter M;Pontifex MB;Raine LB;Konkel A;Hillman CH;Cohen NJ;Kramer AF
通讯作者：
Kramer AF
影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ
影响因子：
2.9
作者：
Chaddock, Laura;Erickson, Kirk I.;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
影响因子：
5.7
作者：
Esteban-Cornejo, Irene;Mora-Gonzalez, Jose;Ortega, Francisco B.
通讯作者：
Ortega, Francisco B.